Candida auris, first identified in 2009 in Japan, has rapidly emerged as a global public health threat, now spanning more than 45 countries. Notably resistant to multiple antifungal classes and adept ... 6 months ago

A healthy 2-year-old presented with a 4-week history of painless alopecia and black dots on the occipital scalp. Direct microscopy revealed fungal spores within the hair shaft, consistent with endothr... 6 months ago

This proof-of-concept phase 2 trial evaluated 8 weeks of bedaquiline monotherapy in nine Brazilian patients with untreated multibacillary leprosy. The primary endpoint reduction in Mycobacterium lepra... 6 months ago

This large cluster-randomized trial (AVENIR) in Niger evaluated the mortality impact of twice-yearly azithromycin distributions to children. Communities were assigned to: (1) azithromycin for children... 6 months ago

A 30-year-old man presented with a 6-month history of depressed lesions on his back. Initially mistaken for scars, the patient denied prior acne, trauma, or burns. Exam revealed well-demarcated erythe... 6 months ago

Reflecting on the Covid-19 pandemic, this Perspective outlines biomedical and ethical priorities for anticipating future pandemics. It highlights lessons on vaccine innovation, gaps in vaccine distrib... 6 months ago

A 58-year-old man with prior splenectomy presented with 3 weeks of fatigue, fever, anorexia, headache, and jaundice. He lived on a farm in upstate New York. Exam revealed scleral icterus and mild righ... 6 months ago

This NEJM letter investigates the neutralization capacity of a lab-synthesized version of pemivibart (Vivyd), a monoclonal antibody authorized for Covid-19 prophylaxis in immunocompromised individuals... 6 months ago

In June 2019, a tick-bitten patient in Inner Mongolia presented with fever and multiorgan dysfunction, leading to the discovery of a novel orthonairovirus Wetland virus (WELV), via next-generation seq... 6 months ago

This correspondence describes a stillbirth associated with vertical transmission of Oropouche virus (OROV) in a previously unaffected region of Ceará, Brazil. The 40-year-old pregnant woman presented... 6 months ago

This case profiles a 56-year-old woman with end-stage liver disease secondary to metabolic dysfunction-associated steatohepatitis, who presented with subacute confusion, abdominal pain, and a worsenin... 6 months ago

This case concerns a previously healthy 47-year-old man with acute onset of confusion, myalgias, and kidney failure. Initial labs revealed severe rhabdomyolysis, hyperkalemia, hyponatremia, metabolic ... 6 months ago

This case concerns a 30-year-old woman, six days postpartum, presenting with fever, abdominal pain, and evolving skin ulcers. Initial evaluation revealed elevated white-cell count, uterine tenderness,... 6 months ago

This case describes a 30-month-old boy hospitalized three times over four weeks for recurrent fever, respiratory symptoms, limp, and elevated inflammatory markers. Imaging revealed pulmonary opacities... 6 months ago

   This case details a 22-year-old woman transferred for acute headache, fever, respiratory failure, and multiorgan findings. Initial symptoms included nausea, myalgias, photophobia, and con... 6 months ago

   A 24-year-old man was admitted in March 1923 with acute fever, pleuritic chest pain, chills, dyspnea, and productive cough with pinkish and purulent sputum. Physical findings included elevated te... 6 months ago

This editorial summarizes an NEJM audio interview recorded on February 6, 2023, featuring Drs. Eric Rubin, Lindsey Baden, Barney Graham, and Stephen Morrissey. The discussion focuses on the future of ... 6 months ago

This editorial summarizes an NEJM audio interview recorded on January 17, 2023, featuring Drs. Eric Rubin, Lindsey Baden, and Stephen Morrissey. The editors assess the immunity conferred by prior SARS... 6 months ago

This phase 3 noninferiority trial compares the oral antiviral VV116 to nirmatrelvir–ritonavir in symptomatic adults with mild-to-moderate Covid-19 at high risk for progression. Conducted in Shanghai... 6 months ago

This correspondence describes a California-wide collaboration to monitor mpox (formerly monkeypox) outbreaks via wastewater-based surveillance. The authors implemented MPXV-specific PCR assays at nine... 6 months ago

This editorial summarizes an NEJM audio interview recorded on January 30, 2023, with Drs. Eric Rubin, Lindsey Baden, and Stephen Morrissey. The discussion centers on a recent FDA advisory committee me... 6 months ago

This article explores the implications of ending the continuous Medicaid enrollment provision established during the Covid-19 pandemic under the Families First Coronavirus Response Act. Authors outlin... 6 months ago

This brief case report presents a 29-year-old man with tuberculous optochiasmatic arachnoiditis, a rare complication of tuberculous meningitis. Despite ongoing treatment for gastrointestinal TB, he de... 6 months ago

   This randomized, open-label, noninferiority trial evaluates whether a treatment strategy using an initial 8-week regimen can achieve clinical outcomes comparable to standard 6-month rifam... 6 months ago

   This editorial summarizes an NEJM audio interview recorded on February 21, 2023, featuring Drs. Eric Rubin, Lindsey Baden, and Stephen Morrissey. The discussion focuses on the ongoing tra... 6 months ago

This article traces the decades-long evolution of vaccine development for respiratory syncytial virus (RSV), highlighting key discoveries from the 1960s vaccine failure to recent breakthroughs in stru... 6 months ago

This editorial summarizes an audio interview with NEJM editors discussing prospects for emerging Covid-19 treatments. The conversation, recorded on February 21, 2023, highlights interferon lambda as a... 6 months ago

This editorial summarizes an audio discussion among NEJM editors reviewing progress and prospects in oral Covid-19 therapeutics. It highlights continued global transmission and the urgent need for ant... 6 months ago

This study assessed the neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.1, which harbor the R346T spike mutation and became dominant globally in late 2022. Across three coho... 6 months ago

   A 29-year-old man with HIV presented with a 2-week history of left-sided abdominal pain. Six months earlier, he had begun treatment for pulmonary tuberculosis, but his regimen was later r... 6 months ago

   This editorial discusses the TRUNCATE-TB trial, which tested a strategic approach to shortening treatment for rifampin-susceptible tuberculosis. Participants were randomized to receive ei... 6 months ago

This international phase 3 trial evaluated the efficacy and safety of a single dose of an adjuvanted RSV prefusion F protein–based candidate vaccine (RSVPreF3 OA) in adults ≥60 years. Among 24,966... 6 months ago

This correspondence analyzes the real-world effectiveness of prior SARS-CoV-2 infections in preventing reinfection with the Omicron BA.2.75 subvariant, using national health data from Qatar. A test-ne... 6 months ago

This article examines the growing threats to the authority and regulatory power of medical licensing and certifying boards, especially in the wake of Covid-19 misinformation. The authors argue that st... 6 months ago

This editorial discusses the INTREST clinical trial evaluating intravenous azithromycin, doxycycline, and their combination for severe scrub typhus treatment. While mortality remained high across all ... 6 months ago

Periprosthetic joint infection (PJI) is a biofilm-driven, prosthesis-specific condition distinct from native bone infection. Symptoms often include pain without fever, while diagnosis is confounded by... 6 months ago

This Clinical Decisions piece presents a vignette of a 72-year-old woman with quadriplegia, neurogenic bladder, and recent nonsevere C. difficile infection treated with fidaxomicin. On admission for a... 6 months ago

A 42-year-old woman presented with swelling and pain on the right side of her chin, without dental symptoms. Physical exam showed a scabbed skin dimple, and intraoral inspection revealed discoloration... 6 months ago

   This correspondence reports on the neutralization capacity of ZF2001 (homotypic RBD-dimer vaccine), inactivated-virus vaccines, and chimeric RBD-dimer immunogens against emerging SARS-CoV... 6 months ago

This clinical letter compares neutralizing antibody responses in adults ≥55 years after receiving a fourth dose of either the original BNT162b2 monovalent vaccine or the updated BA.4–BA.5 bivalent... 6 months ago