Automated insulin delivery (AID) systems have shown benefits for patients with type 1 diabetes, but their role in managing insulin-treated type 2 diabetes remains unclear. This 13 week, multicenter, r... 6 months ago

This editorial reflects on the historical, ethical, and clinical evolution of HIV-positive organ donation, culminating in its recognition as standard of care. Elmi Muller recounts the trajectory from ... 6 months ago

This comprehensive review examines the epidemiology, immunopathogenesis, diagnosis, treatment, and prevention of tuberculosis (TB) in people with HIV infection. TB remains the leading cause of hospita... 6 months ago

This case chronicles the diagnostic journey of an 8-year-old girl with prolonged fever, pharyngitis, and cervical lymphadenopathy during a summer visit to Nantucket, Massachusetts. Initially treated f... 6 months ago

   A 70-year-old man with rheumatoid arthritis and immunosuppressive therapy presented with a 7-day history of painful genital and inner thigh lesions and new-onset urinary difficulty. Physi... 6 months ago

This Perspective examines the evolving crisis of medical expertise and trust in the U.S., especially highlighted by the Covid-19 pandemic. Drawing on historical events from the rise of cultural medica... 6 months ago

This randomized trial conducted in Kenya tested whether fractional doses (20% and 40%) of 10-valent (PCV10) and 13-valent (PCV13) pneumococcal conjugate vaccines are noninferior to full doses in immun... 6 months ago

This firsthand account documents the clinical and ethical decision-making of a critical care physician during Rwanda’s first Marburg virus disease (MVD) outbreak in September–October 2024. The nar... 6 months ago

   This letter outlines unusual clinical and laboratory features of HIV infection during long-acting cabotegravir (CAB-LA) preexposure prophylaxis (PrEP), observed in the HPTN 083 and 084 tr... 6 months ago

A previously healthy 10-year-old boy presented with a 4-day history of progressive eyelid bruising following weeks of intensifying dry cough. He had no history of trauma or clotting disorders and was ... 6 months ago

A previously healthy 30-year-old man developed an extensive, itchy rash over six months during migration from Turkey. Despite topical antifungal and corticosteroid creams, his condition worsened. Exam... 6 months ago

   A 44-year-old man with Crohn’s disease receiving infliximab therapy presented with a two-day history of facial rash. His daughter had recently experienced pharyngitis and his mother had... 6 months ago

This multi-article Perspective series showcases innovative responses to inequity in U.S. health care delivery. Initiatives span trauma-informed community storytelling, mentorship for underrepresented ... 6 months ago

This brief report describes a 58 year old woman with severe ankylosing spondylitis and consanguineous parentage who exhibited undetectable vitamin D levels despite supplementation. Mass spectrometry r... 6 months ago

This multicenter, randomized, placebo controlled trial investigated whether vitamin D₃ supplementation (4000 IU/day) could prevent type 2 diabetes in 2423 high risk adults with prediabetes. Over a m... 6 months ago

This editorial evaluates the findings of the VITAL trial, a large scale randomized study testing vitamin D₃ (2000 IU/day) and marine omega3 fatty acids (1 g/day) for primary prevention of cance... 6 months ago

This editorial explores the progress and challenges in preventing type 1 diabetes mellitus (T1DM), an autoimmune disease targeting pancreatic beta cells. The authors highlight a phase 2 trial of ... 6 months ago

This editorial discusses the advancements in automated insulin delivery systems for patients with type 1 diabetes, focusing on hybrid closed loop systems like the Tandem Control-IQ. A 6 month multicen... 6 months ago

In patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke, the addition of ticagrelor to aspirin was evaluated for its efficacy and safet... 6 months ago

This clinical decision article examines whether to initiate levothyroxine treatment in a 31 year old woman with normal thyroid function but positive thyroid peroxidase antibodies (TPOAb) and a history... 6 months ago

This article explores the link between elevated branched chain amino acids (BCAAs) and insulin resistance in diabetes, highlighting the role of brown adipose tissue (BAT) in BCAA catabolism. A study b... 6 months ago

This article discusses innovative approaches to overcoming the challenges of oral delivery for macromolecular drugs, such as peptides and proteins, which are often unstable or poorly absorbed in the g... 6 months ago

This article explores the role of biomechanical forces in determining the fate of pancreatic progenitor cells, particularly their differentiation into endocrine islet cells. The study by Mamidi et al.... 6 months ago

This 6 month randomized, multicenter trial evaluated the efficacy and safety of a closed loop insulin delivery system (artificial pancreas) compared to a sensor augmented pump in patients with type 1 ... 6 months ago

This 52 week randomized, controlled trial evaluated the safety and efficacy of bempedoic acid in reducing LDL cholesterol levels among patients with hypercholesterolemia receiving maximally tolerated ... 6 months ago

This cluster-randomized trial assessed whether a reduced schedule of the 10-valent pneumococcal conjugate vaccine (PCV10) using one primary dose and one booster (1p+1), was noninferior to standard sch... 6 months ago

This study evaluates the efficacy of ring vaccination using the rVSV-ZEBOV-GP vaccine during the 2018–2020 Ebola virus disease outbreak in eastern Democratic Republic of Congo (DRC), a context marke... 6 months ago

A 60-year-old man with hypertension presented with hemoptysis and painful cervical masses. Imaging revealed enhancing supraclavicular fluid collections and a cavitary pulmonary lesion. Histopathology ... 6 months ago

A 10 yearold girl presented with headaches and poor growth, accompanied by clinical findings of dry skin and growth below the third percentile for height. Laboratory tests revealed markedly elevated t... 6 months ago

This Perspective critiques the U.S. government's early response to emerging H5N1 influenza outbreaks in farm animals and agricultural workers, noting echoes of the systemic failures during the Covid-1... 6 months ago

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors that arise from chromaffin cells and can lead to excessive catecholamine secretion, posing significant diagnostic and therapeutic ch... 6 months ago

This comprehensive review redefines cryoglobulinemia as two distinct clinical entities: type I, a hyperviscosity-driven vasculopathy linked to monoclonal gammopathies; and types II/III (mixed), an imm... 6 months ago

This editorial reviews a phase 3 trial of ziresovir—a fusion inhibitor—for infants hospitalized with respiratory syncytial virus (RSV) in China. Ziresovir significantly improved clinical scores an... 6 months ago

A 26-year-old man presented with a 2-month history of a painless, reddish growth on the left eye. Examination showed a sessile conjunctival mass with visible vascular fronds and an episcleral feeder v... 6 months ago

A preterm male infant born at 31 weeks’ gestation via cesarean section for fetal distress was noted to have hepatomegaly on day 1 of life, without rash, lymphadenopathy, or splenomegaly. Lab results... 6 months ago

This editorial contextualizes new trial findings on xalnesiran, an siRNA targeting HBV surface antigen administered alone or with immunomodulators (pegylated interferon alfa-2a or ruzotolimod) in pati... 6 months ago

This essay explores the psychological aftermath of the Covid-19 pandemic through the lens of collective trauma, noting the enduring emotional toll on U.S. society. It emphasizes disparate impacts on m... 6 months ago

A 26-year-old man presented with a week of fevers and bloody stools following condomless receptive anal intercourse with a new male partner. Physical exam revealed only a small external hemorrhoid, wi... 6 months ago

This interactive case discussion evaluates whether empirical antibiotics or chest radiography should guide treatment for a febrile 4-year-old with presumed pneumonia. Expert essays debate clinical jud... 6 months ago

This essay honors the 2024 Lasker-Bloomberg Public Service Award recipients, Drs. Quarraisha and Salim Abdool Karim, highlighting their expansive contributions to science, public health, and societal ... 6 months ago