This serologic study evaluates live-virus neutralization of emergent SARS-CoV-2 omicron subvariants (BA.2.75.2, BQ.1.1, and XBB) in serum samples from participants who received either one monovalent b... 6 months ago

This clinical vignette describes a premature infant born at 32 weeks gestation who presented with vesicular lesions immediately after delivery. The neonate had no evidence of disseminated infection, a... 6 months ago

This letter to the editor describes a cluster of 21 mpox (MPXV) cases traced to piercing or tattooing procedures at a parlor in Cadiz, Spain between July 6–19, 2022. Patients, many of whom were fema... 6 months ago

This multimedia Perspective includes a short narrative titled Venkamma's Dowry and an accompanying “Double Take” documentary video. The written piece offers a brief, evocative anecdote capturing m... 6 months ago

This Perspective article argues that the U.S. has failed to develop public health infrastructure capable of equitably reaching vulnerable communities during crises. Despite progress in HIV prevention,... 6 months ago

   This multicenter, double-blind, randomized trial (INTREST) compared intravenous doxycycline, azithromycin, and combination therapy for severe scrub typhus across 794 patients aged ≥15 y... 6 months ago

This Perspective article argues that the U.S. has failed to develop public health infrastructure capable of equitably reaching vulnerable communities during crises. Despite progress in HIV prevention,... 6 months ago

   This correspondence reports on a case series of 55 hemodialysis patients who had received four prior SARS-CoV-2 vaccinations and were monitored before and after a fifth dose of a bivalent... 6 months ago

This correspondence presents results from an extension of a phase 2 randomized trial evaluating the immunogenicity of a fourth homologous dose of the NVX-CoV2373 (Novavax) recombinant spike protein va... 6 months ago

This Perspective explores the precarious legal and operational status of health care in U.S. correctional facilities. Although the Supreme Court’s 1976 Estelle v. Gamble decision affirmed incarcerat... 6 months ago

This Perspective from CMS leaders discusses the alignment of quality measures across federal programs through the newly introduced Universal Foundation. With coverage affecting over 150 million Americ... 6 months ago

A previously healthy 54-year-old man presented with bloody diarrhea and cutaneous lesions. Examination revealed signs of advanced immunosuppression, confirmed by HIV diagnosis with a CD4 count of 45 a... 6 months ago

This Perspective reflects on the evolving impact of Covid-19 and advocates for nuanced public health strategies beyond the emergency phase. While many perceive the pandemic as over, SARS-CoV-2 continu... 6 months ago

This clinical study assesses the safety, immunogenicity, and efficacy of a three-dose 3-µg BNT162b2 vaccine regimen in children aged 6 months to 4 years. Initial phase 1 dose-finding confirmed tolera... 6 months ago

This Perspective outlines how the termination of a declared Public Health Emergency (PHE) in the U.S. affects Emergency Use Authorizations (EUAs) for medical products. It explains the legal basis unde... 6 months ago

This correspondence assesses the effectiveness of monoclonal antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB. Researchers found that all tested monoclonal antibodi... 6 months ago

This phase 2b, randomized, double-blind, placebo-controlled trial (CYPRESS) evaluated the efficacy, immunogenicity, and safety of a single-dose Ad26.RSV.preF-RSV preF protein vaccine in adults aged 65... 6 months ago

This nationwide matched case-control study evaluated the effectiveness of the four-component meningococcal group B vaccine (4CMenB) in children under 60 months of age in Spain. Among 306 lab-confirmed... 6 months ago

This phase 3, randomized, placebo-controlled trial evaluates the efficacy of a single dose of pegylated interferon lambda for treating outpatients with symptomatic Covid-19. Conducted in Brazil and Ca... 6 months ago

This correspondence letter evaluates the drug sensitivity of currently circulating mpox virus isolates from 12 unrelated patients during the global outbreak. The authors tested tecovirimat, cidofovir,... 6 months ago

This Clinical Decisions article presents an interactive case discussion involving a 35-year-old man with intravenous heroin use disorder, presenting with fever, body aches, and a suspected diagnosis o... 6 months ago

This Editorial accompanies an audio interview with NEJM editors Eric J. Rubin, Lindsey R. Baden, and Stephen Morrissey on the ongoing threat of Covid-19, particularly the emergence of new viral varian... 6 months ago

This Original Article reports a retrospective cohort study on the effects of surveillance Covid-19 testing among staff in 13,424 U.S. skilled nursing facilities from 2020 to 2022. Researchers evaluate... 6 months ago

This Editorial accompanies an audio interview with NEJM editors Eric J. Rubin, Lindsey R. Baden, and Stephen Morrissey on the ongoing threat of Covid-19, particularly the emergence of new viral varian... 6 months ago

This Images in Clinical Medicine case describes a 17-year-old girl from China diagnosed with condylomata lata, a manifestation of secondary syphilis. She presented with a 1-month history of itchy geni... 6 months ago

This Perspective article explores the complexities and missteps in global polio eradication efforts, particularly in light of vaccine-derived poliovirus (cVDPV) outbreaks. Authored by leading virologi... 6 months ago

This Images in Clinical Medicine report documents a case of cerebral cystic echinococcosis in a 14-year-old boy from rural India. The patient presented with episodic headaches and vomiting, and was fo... 6 months ago

This Images in Clinical Medicine report describes a rare case of primary cerebral alveolar echinococcosis in a 17-year-old boy from China. The patient presented with neurological symptoms including di... 6 months ago

This perspective by Paul A. Offit critically examines the development and deployment of bivalent mRNA Covid-19 vaccines designed to target Omicron variants BA.4 and BA.5. It recounts the timeline of v... 6 months ago

This perspective article explores systemic inequities in global health research, emphasizing the underrepresentation of researchers and institutions from the Global South. It argues that current fundi... 6 months ago

This correspondence reports the emergency department use of F(ab')₂ antivenom for scorpion envenomation in Arizona over a 5-year period (2017–2021). The authors describe 252 patients treated acros... 6 months ago

This comprehensive review summarizes current evidence on the use of antiretroviral therapy (ART) during pregnancy and its association with adverse maternal and fetal outcomes. It highlights that while... 6 months ago

This correspondence reports findings from a study assessing neutralizing antibody and T-cell responses following administration of bivalent mRNA Covid-19 boosters targeting the BA.4–BA.5 variants. C... 6 months ago

The article explores the feasibility and promise of a multivalent mRNA influenza vaccine, building on the technological advancements seen during the Covid-19 pandemic. It discusses the use of nucleosi... 6 months ago

A 70-year-old woman presented with persistent right upper quadrant abdominal pain and systemic symptoms including fever, sweating, fatigue, and weight loss. Imaging and biopsy revealed a hepatic absce... 6 months ago

A 76-year-old man presented with exertional dyspnea and fatigue, progressing over one month. Despite normal cardiopulmonary findings, his condition revealed anemia, thrombocytopenia, elevated liver en... 6 months ago

A 70-year-old kidney transplant recipient with a complex medical history including ANCA-associated vasculitis, coronary artery disease, diabetes, and recent immunosuppressive therapy was admitted with... 6 months ago

A 67-year-old man with a history of interstitial lung disease, previously diagnosed Covid-19 pneumonia, and immunosuppressive therapy was admitted with fever, myalgias, and vomiting. Despite prior tre... 6 months ago

This technical report by the European Commission’s Joint Research Centre (JRC) presents a comprehensive overview of the smart home ecosystem, emphasizing its energy implications across Europe. It co... 6 months ago

   This systematic review examines the benefits and barriers of smart home health technologies (SHHTs) in caregiving for older adults, based on 163 empirical studies published between 2000 a... 6 months ago