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2782 Articles
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Therapeutic Plasma Exchange in Vaccine-Induced Immune Thrombotic Thrombocytopenia
VITT, vaccine-induced thrombosis, platelet factor 4, therapeutic plasma exchange...
VITT, vaccine-induced thrombosis, platelet factor 4, therapeutic plasma exchange, PF4 ELISA, intravenous immune globulin, rituximab, Covid-19 vaccine, refractory thrombocytopenia, ChAdOx1 nCoV-19

This correspondence describes therapeutic plasma exchange (TPE) as a potential treatment for vaccine-induced immune thrombotic thrombocytopenia (VITT) refractory to first-line therapy. Three patients ... 2 days ago

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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19
TTACC, ACTIV-4a, and REMAP-CAP Investigators* (lead authors include: Ewan C. Gol...
Covid-19, therapeutic anticoagulation, heparin, noncritically ill patients, organ support-free days, thromboprophylaxis, randomized trial, D-dimer, bleeding risk, ICU-level support

This multicenter randomized trial assessed whether therapeutic-dose heparin improves outcomes in hospitalized noncritically ill Covid-19 patients. A total of 2219 participants across 9 countries were ... 2 days ago

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
REMAP-CAP, ACTIV-4a, and ATTACC Investigators* (with equal contributions by Ewan...
Covid-19, therapeutic anticoagulation, heparin, ICU, organ support-free days, randomized trial, thromboprophylaxis, bleeding risk, survival outcome, multiplatform trial

This international multiplatform randomized trial investigated whether therapeutic-dose heparin improves outcomes in critically ill patients with Covid-19. A total of 1098 patients were randomized to ... 2 days ago

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The Importance of Context in Covid-19 Vaccine Safety
Grace M. Lee
Covid-19 vaccine, BNT162b2, vaccine safety, myocarditis, SARS-CoV-2 infection, adverse events, public health, surveillance, benefit-risk balance, pandemic response

This editorial emphasizes the importance of contextualizing vaccine safety data during a pandemic. It revisits the 1976 swine flu vaccination program, highlighting how early Guillain-Barré syndrome r... 2 days ago

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The Evolving Post-PCI Antithrombotic Therapies
E. Magnus Ohman
PCI, antithrombotic therapy, dual antiplatelet therapy, bleeding risk, drug-eluting stents, abbreviated therapy, noninferiority trial, ischemic events, Valgimigli trial, cardiovascular outcomes

This editorial explores evolving strategies for post–percutaneous coronary intervention (PCI) antithrombotic therapy, especially in patients with high bleeding risk. It highlights the Valgimigli et ... 2 days ago

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Surviving Covid-19 with Heparin?
Hugo ten Cate
Covid-19, heparin, LMWH, thrombosis, venous thromboembolism, anticoagulation, critical illness, moderate illness, organ support, bleeding risk

This editorial reviews evolving evidence on anticoagulation strategies for hospitalized Covid-19 patients, emphasizing the role of heparin. Patients with moderate illness appear to benefit from therap... 2 days ago

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SGLT2 Inhibition in Heart Failure with a Preserved Ejection Fraction — A Win against a Formidable Foe
Mark H. Drazner
heart failure, preserved ejection fraction, SGLT2 inhibitors, empagliflozin, EMPEROR-Preserved trial, cardiovascular outcomes, hospitalization, renal effects, diabetes, HFpEF treatment

This editorial reviews findings from the EMPEROR-Preserved trial, which examined the effects of SGLT2 inhibitors—originally developed for type 2 diabetes—on patients with heart failure with preser... 2 days ago

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Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
Noam Barda, Noa Dagan, Yatir Ben-Shlomo, Eldad Kepten, Jacob Waxman, Reut Ohana,...
vaccine safety, BNT162b2, mRNA vaccine, Covid-19, myocarditis, lymphadenopathy, adverse events, nationwide study, observational cohort, post-vaccination surveillance

This observational study assessed the safety profile of the BNT162b2 mRNA Covid-19 vaccine across a nationwide cohort in Israel. Using matched controls, researchers evaluated 42-day post-vaccination r... 2 days ago

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Vitamin D Supplementation during Pregnancy and the Prevention of Childhood Asthma
Erika von Mutius, M.D., Fernando D. Martinez, M.D.
Vitamin D supplementation, pregnancy, childhood asthma, VDAART trial, recurrent wheeze, prenatal prevention, allergic asthma, respiratory infections

This editorial discusses the Vitamin D Antenatal Asthma Reduction Trial (VDAART), which investigated whether high-dose vitamin D supplementation (4400 IU/day) during pregnancy prevents childhood ... 2 days ago

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Receipt of mRNA Vaccine against Covid-19 and Myocarditis
Alida L.P. Caforio
myocarditis, Covid-19 vaccine, BNT162b2, mRNA vaccine, young males, vaccine hesitancy, diagnostic criteria, endomyocardial biopsy, public health, editorial

This editorial discusses myocarditis as a rare but notable side effect associated with the BNT162b2 mRNA Covid-19 vaccine, particularly in young males. Drawing on two retrospective studies from Israel... 2 days ago

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Uterine-Artery Embolization or Myomectomy for Uterine Fibroids
Isaac Manyonda, Ph.D., Anna-Maria Belli, F.R.C.R., Mary-Ann Lumsden, M.D., Jonat...
Uterine fibroids, myomectomy, uterine-artery embolization (UAE), quality of life, UFS-QOL, hysterectomy avoidance, randomized trial, FEMME study

This multicenter randomized trial compared uterine artery embolization (UAE) and myomectomy in 254 women with symptomatic uterine fibroids who wished to avoid hysterectomy. At 2 ye... 2 days ago

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Pollution and the Heart
Sanjay Rajagopalan, Philip J. Landrigan
pollution, cardiovascular disease, air pollution, PM₂.₅, toxic metals, endocrine disruptors, fossil fuels, hypertension, diabetes, global health

   This comprehensive review explores the relationship between pollution and cardiovascular disease, emphasizing pollution as a major but often neglected risk factor. It details how air poll... 2 days ago

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Universal Screening for SARS-CoV-2 in Women Admitted for Delivery
SARS-CoV-2, Covid-19, universal screening, pregnancy, asymptomatic infection, la...
Desmond Sutton, M.D., Karin Fuchs, M.D., M.H.A., Mary D’Alton, M.D., Dena Goffman, M.D.

This correspondence reports findings from universal SARS-CoV-2 testing implemented for 215 pregnant women admitted for delivery at two New York City hospitals during the early Covid-19 pande... 2 days ago

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PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia
Yves Gruel, Caroline Vayne, Jérôme Rollin, Claire Pouplard, Hubert Galinat, Ol...
VITT, PF4 immunoassay, ChAdOx1 nCoV-19, thrombocytopenia, platelet activation, serotonin release assay, vaccine safety, ELISA, IdeS, monoclonal antibody IV.3

This correspondence evaluates platelet factor 4 (PF4) immunoassay performance in diagnosing vaccine-induced immune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 vaccination. Plasma samples ... 2 days ago

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Point-of-Care Ultrasonography
José L. Díaz-Gómez, Paul H. Mayo, Seth J. Koenig
POCUS, bedside ultrasound, handheld imaging, diagnostic accuracy, cardiac arrest, procedural guidance, AI in ultrasound, clinical training, consultative ultrasonography, cost-effectiveness

   This review article discusses point-of-care ultrasonography (POCUS), which refers to ultrasonographic imaging performed and interpreted by the treating clinician at the bedside. It highli... 2 days ago

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Umbilical Cord Knot
Francesca Arezzo, M.D., Giuseppe Muzzupapa, M.D.
Umbilical cord knot, monochorionic twins, monoamniotic twins, fetal distress, variable decelerations, cesarean section, neonatal intensive care

This Images in Clinical Medicine entry reports a rare case of complex umbilical cord knotting in monochorionic, monoamniotic twins delivered via cesarean section at 32 weeks of ges... 2 days ago

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Oral versus Intravenous Antibiotics for Endocarditis
Jehan Chowdhury, Robin Patel, Henry Chambers
infective endocarditis, intravenous antibiotics, oral therapy, Staphylococcus aureus, POET trial, drug use, treatment adherence, patient-centered care, outpatient therapy, antimicrobial management

This interactive editorial explores antibiotic treatment strategies for methicillin-sensitive Staphylococcus aureus endocarditis in a patient with active intravenous drug use. Two expert viewpoints ar... 2 days ago

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No Correlation between Anti-PF4 and Anti–SARS-CoV-2 Antibodies after ChAdOx1 nCoV-19 Vaccination
Günalp Uzun, Karina Althaus, Tamam Bakchoul
VITT, ChAdOx1 nCoV-19, anti-PF4 antibodies, SARS-CoV-2, spike protein, platelet factor 4, antibody cross-reactivity, vaccine safety, thrombosis, ELISA

This correspondence investigates the potential immunological link between SARS-CoV-2 vaccination and vaccine-induced immune thrombotic thrombocytopenia (VITT), focusing on antibody responses. Research... 2 days ago

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Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation
teffen Desch, Anne Freund, Ibrahim Akin, Michael Behnes, Michael R. Preusch, Tho...
cardiac arrest, coronary angiography, ST-segment elevation, randomized trial, resuscitation, TOMAHAWK trial, 30-day mortality, neurologic outcome, intensive care, clinical strategy

This multicenter randomized trial evaluated the effect of immediate coronary angiography versus delayed/selective angiography in 554 patients with resuscitated out-of-hospital cardiac arrest of possib... 2 days ago

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Twin Anemia Polycythemia Sequence
Joana Araújo Pereira, M.D., Marina Sousa Gomes, M.D.
Twin anemia polycythemia sequence (TAPS), twin-to-twin transfusion syndrome (TTTS), monochorionic twins, placental anastomoses, neonatal anemia

This Images in Clinical Medicine entry describes a case of twin anemia polycythemia sequence (TAPS) in monochorionic, diamniotic twins born at 31 weeks of gestation. The first twin... 2 days ago

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Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
Guy Witberg, Noam Barda, Sara Hoss, Ilan Richter, Maya Wiessman, Yaron Aviv, Tzl...
myocarditis, BNT162b2, mRNA vaccine, Covid-19 vaccination, Israel, Clalit Health Services, cardiac inflammation, vaccine surveillance, adverse events, young males

This retrospective cohort study evaluated myocarditis incidence following administration of the BNT162b2 mRNA Covid-19 vaccine within Israel’s largest healthcare organization. Of 2.56 million vaccin... 2 days ago

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Myocarditis after Covid-19 mRNA Vaccination
Amanda K. Verma, Kory J. Lavine, Chieh-Yu Lin
myocarditis, Covid-19 vaccine, mRNA vaccination, BNT162b2, mRNA-1273, histological confirmation, vaccine safety, cardiac inflammation, case report, post-vaccination myocarditis

This correspondence reports two adult cases of histologically confirmed myocarditis occurring within 2 weeks of Covid-19 mRNA vaccination. Patient 1, a 45-year-old woman, developed severe left ventric... 2 days ago

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Transgender Women on College Athletic Teams — The Case of Lindsay Hecox
Transgender athletes, Title IX, Lindsay Hecox, Idaho law, testosterone, gender i...
Janet Dolgin, Ph.D., J.D.

This perspective article examines the implications of Idaho’s Fairness in Women’s Sports Act, which bars transgender girls and women from participating in female athletic teams. The law, chal... 2 days ago

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Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel
Dror Mevorach, Emilia Anis, Noa Cedar, Michal Bromberg, Eric J. Haas, Eyal Nadir...
myocarditis, BNT162b2, Covid-19 vaccine, mRNA vaccine, Israel, surveillance, vaccine safety, adverse events, young males, rate ratios

This retrospective cohort study from Israel examined the incidence of myocarditis following the BNT162b2 mRNA Covid-19 vaccine. Active surveillance was conducted between December 2020 and May 2021. Of... 2 days ago

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The Modern Epidemic of Syphilis
Khalil G. Ghanem, M.D., Ph.D., Sanjay Ram, M.B., B.S., Peter A. Rice, M.D.
Syphilis, Treponema pallidum, epidemiology, diagnosis, treatment, penicillin, congenital syphilis, neurosyphilis, public health

Syphilis, caused by Treponema pallidum, has resurged in the United States, reaching levels not seen in over two decades. This review explores the epidemiology, clinical manifestations, diagnostic... 2 days ago

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Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A
Lindsey A. George, Paul E. Monahan, M. Elaine Eyster, Spencer K. Sullivan, Marga...
hemophilia A, AAV gene therapy, SPK-8011, factor VIII expression, bleeding reduction, liver-targeted therapy, immune response, clinical trial, hepatocyte expression

   This phase 1–2 clinical trial investigated SPK-8011, an adeno-associated viral (AAV) vector designed to promote hepatocyte expression of factor VIII in adult men with hemophilia A. Amon... 2 days ago

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Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction
Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman...
Vitamin D, prenatal supplementation, asthma prevention, recurrent wheeze, childhood asthma, lung function, clinical trial

This study investigated the long-term effects of prenatal vitamin D supplementation on asthma and recurrent wheeze in children through age 6. A randomized, double-blind trial compared high dose (4400 ... 2 days ago

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Ruthless Health Law
R. Alta Charo
Affordable Care Act (ACA), Supreme Court, Ruth Bader Ginsburg, health law, reproductive rights, equality, individual mandate, California v. Texas

This perspective article examines the potential consequences of a Supreme Court challenge to the Affordable Care Act (ACA) in California v. Texas, particularly in the absence of Justice Ruth Bade... 2 days ago

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Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants
Shabir A. Madhi, Fernando P. Polack, Pedro A. Piedra, Flor M. Munoz, Adrian A. T...
Respiratory syncytial virus (RSV), maternal vaccination, pregnancy, infant protection, lower respiratory tract infection, vaccine efficacy, clinical trial

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants. This randomized, observer-blind, placebo-controlled phase 3 trial evaluated the efficacy o... 2 days ago

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Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Craig R. Cohen, Michael R. Wierzbicki, Audrey L. French, Sheldon Morris, Sara Ne...
Bacterial vaginosis, Lactobacillus crispatus CTV-05, Lactin-V, recurrence prevention, randomized controlled trial, vaginal microbiota

Bacterial vaginosis (BV) affects 15–50% of women of reproductive age, with high recurrence rates after antibiotic treatment. This randomized, double-blind, placebo controlled phase 2b trial evaluate... 2 days ago

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Moving the Goalposts for Blood Pressure — Time to Act
Mark R. Nelson
blood pressure, hypertension, cardiovascular risk, STEP trial, systolic targets, clinical practice, disease model, patient-centered care, intensive therapy

This editorial explores findings from the STEP trial conducted in China, which confirmed cardiovascular benefits of intensive systolic blood pressure targets in older adults. It critiques traditional ... 2 days ago

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Modeling Human Cardiac Chambers with Organoids
Deepak Srivastava
cardiac organoids, cardioids, congenital heart defects, stem cells, myocardial development, epicardium, endocardium, hypoplastic left heart syndrome, cardiac injury, regenerative medicine

This article highlights recent advances in modeling human cardiac development using organoids. The featured study by Hofbauer et al. presents the creation of cardioids—three-dimensional, self-organi... 2 days ago

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Milvexian for the Prevention of Venous Thromboembolism
Jeffrey I. Weitz, John Strony, Walter Ageno, David Gailani, Elaine M. Hylek, Mic...
milvexian, factor XIa inhibitor, venous thromboembolism, anticoagulation, knee arthroplasty, bleeding risk, enoxaparin, thrombosis prevention

This phase 2 randomized trial evaluated the efficacy and safety of milvexian, an oral Factor XIa inhibitor, for preventing venous thromboembolism in 1242 patients undergoing knee arthroplasty. Partici... 2 days ago

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Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock
Rebecca Mathew, Pietro Di Santo, Richard G. Jung, Jeffrey A. Marbach, Jordan Hut...
cardiogenic shock, milrinone, dobutamine, inotropic therapy, randomized trial, heart failure, mechanical circulatory support, renal replacement therapy

This randomized clinical trial compares milrinone and dobutamine in patients with cardiogenic shock. The study enrolled 192 participants, assigning them to either drug to assess outcomes like mortalit... 2 days ago

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Preterm Birth and 17OHP — Why the FDA Should Not Withdraw Approval
Michael F. Greene, Mark A. Klebanoff, David Harrington
Preterm birth prevention, 17OHP, 17 alpha-hydroxyprogesterone caproate, FDA approval, racial disparities, maternal-fetal medicine

This perspective article argues against the FDA’s proposed withdrawal of approval for 17 alpha hydroxyprogesterone caproate (17OHP), a drug used to prevent recurrent preterm birth in high risk women... 2 days ago

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Delaying Pregnancy during a Public Health Crisis — Examining Public Health Recommendations for Covid-19 and Beyond
Sonja A. Rasmussen, Anne Drapkin Lyerly, Denise J. Jamieson
COVID-19, pregnancy delay, public health recommendations, reproductive autonomy, ethics, Zika virus, H1N1 influenza, maternal health, risk mitigation

This perspective article explores the ethical and public health considerations surrounding recommendations to delay pregnancy during public health emergencies, focusing on the COVID-19 pandemic. Drawi... 2 days ago

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Pemphigoid Gestationis
Paolo Agostinis, Roberta M. Antonello
Pemphigoid gestationis, herpes gestationis, autoimmune blistering disorder, pregnancy, dermatology, glucocorticoids, anti-bullous pemphigoid antibodies

This case report describes a 30 year old pregnant woman who presented at 34 weeks of gestation with a pruritic rash that progressed to confluent papules and blisters on her abdomen, thorax, and limbs.... 2 days ago

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Management of Abdominal Aortic Aneurysms
Andres Schanzer, Gustavo S. Oderich
abdominal aortic aneurysm, endovascular repair, open surgical repair, rupture risk, vascular surgery, EVAR, aneurysm surveillance, repair thresholds

Abdominal aortic aneurysms are defined as having an aortic diameter of more than 3 cm. In the United States, the prevalence is estimated to be 1.4% among individuals aged 50 to 84. Risk factors for de... 2 days ago

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Mitochondrial Replacement in the Clinic
Patrick F. Chinnery
Mitochondrial replacement, mitochondrial DNA (mtDNA), infertility treatment, three-parent babies, pronuclear transfer, spindle transfer, genetic disorders, ethics in medicine

This article discusses the clinical implications of mitochondrial replacement techniques, including their use for preventing severe mitochondrial diseases and treating infertility. The procedure, ofte... 2 days ago

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Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia
Anne A.M.W. van Kempen, P. Frank Eskes, Debbie H.G.M. Nuytemans, Johanna H. van ...
Neonatal hypoglycemia, treatment threshold, psychomotor development, Bayley Scales, randomized trial, noninferiority

This multicenter, randomized, noninferiority trial compared two glucose threshold values for treating asymptomatic moderate hypoglycemia in newborns. The study involved 689 otherwise healthy newborns ... 2 days ago

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