perinatal care, neonatal respiratory distress, U.S. healthcare inequities, relative value units (RVUs), Medicaid reimbursement, hospital closures, maternal mortality
This article, written from the perspective of a neonatologist, reflects on a newborn’s struggle to breathe in the first moments of life and the systemic challenges in U.S. perinatal care. The physic... 4 weeks ago
IgA nephropathy, once considered a benign condition, is now recognized as the most common glomerulopathy worldwide, often progressing to end-stage kidney disease. Despite decades of symptomatic care, ... 4 weeks ago
An 84-year-old man with a history of melanoma on the right forehead, complicated by in-transit metastases to the scalp, developed blue-gray macules after receiving immunotherapy.Seven months after sta... 4 weeks ago
Tubal ectopic pregnancy occurs when a fertilized egg implants in the fallopian tube, posing a serious risk of rupture and hemorrhage. This condition accounts for approximately 2% of pregnancies in Nor... 4 weeks ago
This clinical problem-solving case discusses a 29-year-old man who presented with fever, chills, and joint pain, revealing an unusual dual diagnosis of secondary syphilis and methicillin-resistant Sta... 4 weeks ago
This editorial examines vascular inflammation in atherothrombosis and assesses whether early anti-inflammatory intervention can improve outcomes in patients with acute myocardial infarction.The articl... 4 weeks ago
This correspondence details the use of tirzepatide, a once-weekly dual GLP-1/GIP agonist, in two patients with congenital generalized lipodystrophy type 1 (AGPAT2 variant). Congenital generalized lipo... 4 weeks ago
private equity in health care, financialization, global investments, hospital closures, medical regulations, market consolidation, health care transparency, policy interventions
Private equity investments in global health care have surged, reaching $446 billion between 2018 and 2022. Historically associated with U.S. health care financialization, private equity has expanded i... 4 weeks ago
medical ethics, compassion, homelessness, institutional responsibility, physician self-awareness, societal inequalities, human dignity
This reflective essay explores the complexities of compassion, moral responsibility, and self-awareness in medical practice. The author, a physician, recounts an early morning scene in which a naked w... 4 weeks ago
gender-affirming care, Cass Review, NHS policies, transgender healthcare, randomized controlled trials, informed consent, medical ethics
This article critiques the Cass Review, a report commissioned by England’s National Health Service (NHS) in 2024, which argues that there is insufficient evidence to support gender-affirming care (G... 4 weeks ago
medical ethics, patient care, difficult patients, physician bias, empathy, prejudice in healthcare, palliative reflection, hospital mortality, caregiver burden
This deeply reflective piece explores the ethical and emotional challenges faced by healthcare providers when caring for difficult patients. The author recounts multiple hospital admissions of Mr. M.,... 4 weeks ago
Sonja A. Rasmussen, M.D.; Mary Lou Lindegren, M.D., M.P.H.; Lawrence K. Altman, ...
CDC, MMWR, public health communication, scientific integrity, H5N1 influenza, health advisories, political interference, Trump administration, NIH, FDA
This article examines the implications of a temporary halt on public communications from the Centers for Disease Control and Prevention (CDC) under the Trump administration in early 2025. The directiv... 4 weeks ago
Spironolactone, a mineralocorticoid receptor antagonist, is established in the treatment of heart failure following myocardial infarction (MI). However, its routine use post-MI remains uncertain.This ... 4 weeks ago
A 17-year-old boy from El Salvador was diagnosed with pleural paragonimiasis after a routine chest radiograph at an immigration clinic revealed a pleural effusion. Despite being asymptomatic, further ... 4 weeks ago
Kristen Underhill, D.Phil., J.D.; Kimberly M. Nelson, Ph.D., M.P.H.
informed consent, medical litigation, gender-affirming care, healthcare restrictions, malpractice risks, legislative impact, medical ethics, patient autonomy
Recent legislative efforts in multiple U.S. states have sought to limit access to gender-affirming care, introducing novel legal tactics that may impact informed consent across other medical areas. Wh... 4 weeks ago
secondary syphilis, plaques en prairie fauchée, HIV infection, oral lesions, treponemal testing, rapid plasma reagin, penicillin therapy, infectious diseases
A 29-year-old man with well-controlled HIV infection presented with a painful, whitish discoloration on his tongue for one week. He also reported scrotal ulcers that had resolved over the previous fou... 4 weeks ago
A previously healthy 44-year-old woman presented with mouth ulcers and blistered lips persisting for 11 months, causing pain while eating and unintentional weight loss. She also reported skin blisters... 4 weeks ago
medical education, patient communication, palliative care, emotional intelligence, psychotherapy techniques, cultural sensitivity, doctor-patient interaction
This article examines the challenges of applying standardized communication techniques in medical education and palliative care. The author reflects on a family meeting where a trainee struggled to co... 4 weeks ago
Medical aid in dying (MAID), palliative care, caregiver burden, patient autonomy, end-of-life decisions, physician ethics, metastatic cancer
In this deeply personal narrative, Dr. Hannah Kirsch, a neurointensivist and palliative care researcher, recounts her experience as both a physician and daughter during her mother’s terminal illness... 4 weeks ago
Nonacute subdural hematoma (SDH) is a growing concern among aging populations, particularly with increased use of antiplatelet and anticoagulant therapies. Traditional treatments, including glucocorti... 4 weeks ago
The clinical relevance of microvascular inflammation in kidney transplants remains unclear, posing diagnostic and therapeutic challenges. This multicenter cohort study assessed biopsy specimens from 6... 4 weeks ago
Rwanda’s rapid containment of the 2024 Marburg virus disease (MVD) outbreak demonstrated a transformative model for epidemic response, contrasting historical trends. The outbreak began in September ... 4 weeks ago
Marburg virus disease, Rwanda outbreak, epidemic response, health equity, filovirus infections, supportive care
Rwanda’s rapid containment of the 2024 Marburg virus disease (MVD) outbreak demonstrated a transformative model for epidemic response, contrasting historical trends. The outbreak began in September ... 4 weeks ago
The EMPA-KIDNEY trial previously demonstrated positive cardiorenal effects of empagliflozin, an SGLT2 inhibitor, in patients with chronic kidney disease (CKD). This study assessed whether these benefi... 4 weeks ago
A 46-year-old woman with multiple myeloma presented with hoarseness and a painful sensation while swallowing. She had undergone autologous stem-cell transplantation five years earlier and was receivin... 4 weeks ago
A 35-year-old man with progressive limb weakness, intermittent muscle cramping, fatigue, weight gain, and constipation was diagnosed with hypothyroid myopathy with muscle pseudohypertrophy (Hoffman’... 4 weeks ago
A 55-year-old man with a history of orthotopic liver transplantation developed post-transplantation Kaposi’s sarcoma, which was previously diagnosed in his liver, ventricle, and lymph nodes. A routi... 4 weeks ago
Patients undergoing standard treatment for chronic subdural hematoma have a high risk of treatment failure, with recurrence rates ranging from 5% to 50%. This randomized controlled trial (STEM) examin... 4 weeks ago
food insecurity, nutrition security, malnutrition, public health, global food systems, climate change, poverty, health disparities, sustainable food solutions, policy interventions
Food and nutrition insecurity affects populations globally, with disproportionate harm to those with limited resources. The review highlights its role in malnutrition, communicable and noncommunicable... 4 weeks ago
A 19-year-old man presented with a three-week history of asymptomatic serpiginous eruptions on his neck. As a beach lifeguard in Southern California, he had no history of international travel. Physica... 4 weeks ago
Inflammation plays a key role in adverse cardiovascular events, leading researchers to investigate colchicine as a potential treatment for myocardial infarction. This multicenter, randomized controlle... 4 weeks ago
Patients with IgA nephropathy and severe proteinuria face a high lifetime risk of kidney failure. This phase 3 randomized controlled trial evaluated the efficacy of atrasentan, a selective endothelin ... 4 weeks ago
Chronic kidney disease (CKD) affects 14% of the U.S. population and poses substantial risks for end-stage kidney disease, cardiovascular events, and mortality. Despite therapeutic stagnation, sodium-g... 4 weeks ago
IgA nephropathy, iptacopan, alternative complement pathway, factor B inhibition, glomerulonephritis, proteinuria reduction, renal pathology, clinical trial, complement inhibitors, kidney disease therapy
IgA nephropathy is the most prevalent type of glomerulonephritis, leading to progressive kidney damage due to immune complex deposition. The alternative complement pathway plays a central role in dise... 4 weeks ago
Tumor-induced osteomalacia is the most common acquired form of fibroblast growth factor 23-related hypophosphatemic rickets-osteomalacia (FGF23rHR). However, in 27% to 45% of cases, causative tumors r... 4 weeks ago
Antibody-mediated rejection is a major determinant of allograft survival and has evolved significantly since the era of hyperacute rejection. The Banff Classification of Allograft Pathology, first int... 4 weeks ago
A 62-year-old man presented with postprandial abdominal pain worsening over two years, alongside weight loss, nausea, and an irreducible umbilical hernia. While living in Costa Rica, he was diagnosed ... 4 weeks ago
A 30-year-old woman presented with progressive dysesthesia, worsening headache, and confusion following recent travel to Thailand, Japan, and Hawaii. Initially experiencing burning sensations in her f... 4 weeks ago
A 14-year-old adolescent presented with a 12-month history of joint pain, intermittent blurry vision, and severe bifrontal headaches. Symptoms worsened over three weeks despite ibuprofen use, leading ... 4 weeks ago
A 90-year-old man with atrial fibrillation and dementia presented with sudden-onset dyspnea, which began one hour before admission. The patient had not been receiving anticoagulation therapy due to pr... 4 weeks ago