Unemployment among graduates of tertiary institutions in Nigeria has remained a persistent socio-economic challenge, often attributed to a mismatch between graduates' skills and the demands of the l... 4 months ago

A 32-year-old man with well-controlled HIV presented with a 1-month history of painful forehead nodules. He had engaged in condomless sex with four male partners in the preceding 3 months. Examination... 5 months ago

This multicenter, observational, noninferiority study evaluated the safety of kidney transplantation from deceased donors with HIV to recipients with HIV, comparing outcomes with transplants from dono... 5 months ago

   This double-blind, controlled clinical trial evaluated the safety and efficacy of immunization with a genetically attenuated Plasmodium falciparum parasite (GA2), which arrests late in th... 5 months ago

his letter reports extended efficacy data from the phase 3 RENOIR trial evaluating the bivalent RSVpreF vaccine in adults aged 60 and older across two RSV seasons. Conducted in seven countries, the tr... 5 months ago

This editorial discusses two cost-saving strategies for pneumococcal conjugate vaccine (PCV) programs in low- and middle-income countries: fractional dosing and reduced-dose schedules. Gallagher et al... 5 months ago

A 9-year-old girl presented with a 7-day history of a cheek lesion and 4 days of fever. Initially treated for impetigo, her symptoms persisted. Examination revealed a 3-cm round plaque with crusting, ... 5 months ago

   This Perspective advocates for a whole-system approach to combating antimicrobial resistance (AMR), emphasizing the need to move beyond fragmented interventions toward integrated, sustain... 5 months ago

   This Perspective argues for expanded and coordinated global regulatory capacity to ensure equitable access to diagnostics, therapeutics, and vaccines during future public health emergenci... 5 months ago

This double-blind, cluster-randomized, placebo-controlled trial (TB-CHAMP) evaluated the efficacy and safety of levofloxacin as preventive treatment in 922 children exposed to household contacts with ... 5 months ago

   This retrospective cohort study used U.S. Department of Veterans Affairs health records to assess the cumulative incidence and burden of postacute sequelae of SARS-CoV-2 infection (PASC, ... 5 months ago

Abstract:Transgender and gender nonconforming (trans) individuals face disproportionate incarceration rates in the U.S., yet access to gender affirming surgical care in carceral settings remains limit... 5 months ago

This phase 2–3 double-blind, placebo-controlled trial evaluated the efficacy and safety of oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 among 2736 asymptomatic adults expos... 5 months ago

This 10 year, double blind, randomized, placebo controlled trial investigated the efficacy of infrequent zoledronate administration in preventing vertebral fractures among early postmenopausal women (... 5 months ago

A 38-year-old man with a history of kidney transplantation presented with a 2-week history of burning, hairy lesions on his tongue. He was immunosuppressed with tacrolimus and mycophenolate mofetil. E... 5 months ago

Cardiovascular diseases remain the leading cause of global mortality, with over 19.8 million deaths in 2022, many of which were premature and preventable. This editorial highlights the critical role o... 5 months ago

This prospective, multicenter, matched case-control study assessed the real-world effectiveness of nirsevimab. a long-acting monoclonal antibody against hospitalization for RSV-associated bronchioliti... 5 months ago

Enteral nutrition is a critical intervention for preventing and treating disease related malnutrition in hospitalized adults who cannot meet their nutritional needs orally. This review highlights the ... 5 months ago

This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a 6-month levofloxacin regimen to prevent active tuberculosis among 2041 household contacts of patients wit... 5 months ago

A 50-year-old man from a rural area presented with a 3-day history of left-sided tooth and jaw pain, fever, and shortness of breath. Examination revealed poor dentition, trismus, stridor, and erythema... 5 months ago

This phase 2b randomized, double blind, placebo controlled trial evaluated the efficacy and safety of efruxifermin, a bivalent fibroblast growth factor 21 (FGF21) analogue, in 181 patients with compen... 5 months ago

This Perspective outlines the clinical, epidemiologic, and public health implications of mpox (monkeypox virus, MPXV) infection during pregnancy and breast-feeding. Drawing on recent outbreaks of clad... 5 months ago

This review examines the profound global health impacts of food and nutrition insecurity, affecting 2.33 billion people with moderate to severe food insecurity in 2023. Defined by the FAO as inadequat... 5 months ago

This article chronicles the scientific and clinical breakthroughs behind GLP1 based drugs, which have transformed obesity treatment. The 2024 Lasker DeBakey Award recognized Joel Habener, Svetlana Moj... 5 months ago

This correspondence documents the transcontinental spread of a highly drug-resistant seventh-pandemic Vibrio cholerae O1 El Tor (7PET) strain, sublineage AFR13, from South Asia to East Africa and Euro... 5 months ago

This Sounding Board article presents the 2024 National Academies of Sciences, Engineering, and Medicine (NASEM) definition of long Covid, developed through extensive stakeholder engagement and literat... 5 months ago

This phase 3a trial evaluated the efficacy and safety of coadministered cagrilintide and semaglutide (CagriSema) in adults with overweight or obesity. Participants (N=3417) were randomized to receive ... 5 months ago

This clinical decision article explores the debate over intravenous fluid choice for resuscitation in diabetic ketoacidosis (DKA). A case vignette presents a 34-year-old woman with DKA, hypovolemia, a... 5 months ago

   This editorial discusses the emerging role of levofloxacin as preventive therapy for individuals exposed to multidrug-resistant (MDR) tuberculosis, based on findings from two randomized c... 5 months ago

This clinical image report describes a 20-year-old woman who presented with headache, diplopia, and right eyelid ptosis one week after an influenza diagnosis. Examination revealed oculomotor nerve pal... 5 months ago

Poor nutrition is a leading cause of illness and mortality, contributing to preventable diseases such as cardiovascular disease, diabetes, and cancer. This review explores the vast chemical complexity... 5 months ago

This perspective critiques recent U.S. Congressional proposals to impose nutrition-based restrictions on the Supplemental Nutrition Assistance Program (SNAP), arguing that such changes diverge from gl... 5 months ago

This clinical image report describes a 25-year-old woman with systemic lupus erythematosus (SLE) who presented with a 3-month history of erosive, violaceous plaques in intertriginous areas and scaly e... 5 months ago

This correspondence describes two confirmed cases of highly pathogenic avian influenza (HPAI) A(H5N1) virus infection in dairy farm workers in Michigan, following outbreaks among lactating cows across... 5 months ago

This phase 3a, double-blind, randomized, placebo-controlled trial evaluated the efficacy and safety of once-weekly cagrilintide semaglutide (CagriSema) in adults with overweight or obesity and type 2 ... 5 months ago

This editorial evaluates emerging treatments for IgG4 related disease, a fibroinflammatory condition affecting multiple organs. While glucocorticoids remain the first line therapy, relapses are common... 5 months ago

This editorial discusses the efficacy and safety of automated insulin delivery (AID) systems for type 2 diabetes, based on a clinical trial by Kudva et al. involving 319 insulin treated patients. The ... 5 months ago

This perspective article examines the escalating policy threats to transgender health under the Trump Vance administration, including executive orders restricting federal recognition of gender identit... 5 months ago

This correspondence outlines the immunobridging methodology used to support the Emergency Use Authorization (EUA) of pemivibart, a monoclonal antibody for preexposure prophylaxis of Covid-19 in immuno... 5 months ago

This study identified autoantibodies against PHEX (phosphate-regulating endopeptidase Xlinked) in patients with unexplained acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemic ricket... 5 months ago