This correspondence describes therapeutic plasma exchange (TPE) as a potential treatment for vaccine-induced immune thrombotic thrombocytopenia (VITT) refractory to first-line therapy. Three patients ... 2 days ago

This multicenter randomized trial assessed whether therapeutic-dose heparin improves outcomes in hospitalized noncritically ill Covid-19 patients. A total of 2219 participants across 9 countries were ... 2 days ago

This international multiplatform randomized trial investigated whether therapeutic-dose heparin improves outcomes in critically ill patients with Covid-19. A total of 1098 patients were randomized to ... 2 days ago

This editorial emphasizes the importance of contextualizing vaccine safety data during a pandemic. It revisits the 1976 swine flu vaccination program, highlighting how early Guillain-Barré syndrome r... 2 days ago

This editorial explores evolving strategies for post–percutaneous coronary intervention (PCI) antithrombotic therapy, especially in patients with high bleeding risk. It highlights the Valgimigli et ... 2 days ago

This editorial reviews evolving evidence on anticoagulation strategies for hospitalized Covid-19 patients, emphasizing the role of heparin. Patients with moderate illness appear to benefit from therap... 2 days ago

This editorial reviews findings from the EMPEROR-Preserved trial, which examined the effects of SGLT2 inhibitors—originally developed for type 2 diabetes—on patients with heart failure with preser... 2 days ago

This observational study assessed the safety profile of the BNT162b2 mRNA Covid-19 vaccine across a nationwide cohort in Israel. Using matched controls, researchers evaluated 42-day post-vaccination r... 2 days ago

This editorial discusses the Vitamin D Antenatal Asthma Reduction Trial (VDAART), which investigated whether high-dose vitamin D supplementation (4400 IU/day) during pregnancy prevents childhood ... 2 days ago

This editorial discusses myocarditis as a rare but notable side effect associated with the BNT162b2 mRNA Covid-19 vaccine, particularly in young males. Drawing on two retrospective studies from Israel... 2 days ago

This multicenter randomized trial compared uterine artery embolization (UAE) and myomectomy in 254 women with symptomatic uterine fibroids who wished to avoid hysterectomy. At 2 ye... 2 days ago

   This comprehensive review explores the relationship between pollution and cardiovascular disease, emphasizing pollution as a major but often neglected risk factor. It details how air poll... 2 days ago

This correspondence reports findings from universal SARS-CoV-2 testing implemented for 215 pregnant women admitted for delivery at two New York City hospitals during the early Covid-19 pande... 2 days ago

This correspondence evaluates platelet factor 4 (PF4) immunoassay performance in diagnosing vaccine-induced immune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19 vaccination. Plasma samples ... 2 days ago

   This review article discusses point-of-care ultrasonography (POCUS), which refers to ultrasonographic imaging performed and interpreted by the treating clinician at the bedside. It highli... 2 days ago

This Images in Clinical Medicine entry reports a rare case of complex umbilical cord knotting in monochorionic, monoamniotic twins delivered via cesarean section at 32 weeks of ges... 2 days ago

This interactive editorial explores antibiotic treatment strategies for methicillin-sensitive Staphylococcus aureus endocarditis in a patient with active intravenous drug use. Two expert viewpoints ar... 2 days ago

This correspondence investigates the potential immunological link between SARS-CoV-2 vaccination and vaccine-induced immune thrombotic thrombocytopenia (VITT), focusing on antibody responses. Research... 2 days ago

This multicenter randomized trial evaluated the effect of immediate coronary angiography versus delayed/selective angiography in 554 patients with resuscitated out-of-hospital cardiac arrest of possib... 2 days ago

This Images in Clinical Medicine entry describes a case of twin anemia polycythemia sequence (TAPS) in monochorionic, diamniotic twins born at 31 weeks of gestation. The first twin... 2 days ago

This retrospective cohort study evaluated myocarditis incidence following administration of the BNT162b2 mRNA Covid-19 vaccine within Israel’s largest healthcare organization. Of 2.56 million vaccin... 2 days ago

This correspondence reports two adult cases of histologically confirmed myocarditis occurring within 2 weeks of Covid-19 mRNA vaccination. Patient 1, a 45-year-old woman, developed severe left ventric... 2 days ago

This perspective article examines the implications of Idaho’s Fairness in Women’s Sports Act, which bars transgender girls and women from participating in female athletic teams. The law, chal... 2 days ago

This retrospective cohort study from Israel examined the incidence of myocarditis following the BNT162b2 mRNA Covid-19 vaccine. Active surveillance was conducted between December 2020 and May 2021. Of... 2 days ago

Syphilis, caused by Treponema pallidum, has resurged in the United States, reaching levels not seen in over two decades. This review explores the epidemiology, clinical manifestations, diagnostic... 2 days ago

   This phase 1–2 clinical trial investigated SPK-8011, an adeno-associated viral (AAV) vector designed to promote hepatocyte expression of factor VIII in adult men with hemophilia A. Amon... 2 days ago

This study investigated the long-term effects of prenatal vitamin D supplementation on asthma and recurrent wheeze in children through age 6. A randomized, double-blind trial compared high dose (4400 ... 2 days ago

This perspective article examines the potential consequences of a Supreme Court challenge to the Affordable Care Act (ACA) in California v. Texas, particularly in the absence of Justice Ruth Bade... 2 days ago

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants. This randomized, observer-blind, placebo-controlled phase 3 trial evaluated the efficacy o... 2 days ago

Bacterial vaginosis (BV) affects 15–50% of women of reproductive age, with high recurrence rates after antibiotic treatment. This randomized, double-blind, placebo controlled phase 2b trial evaluate... 2 days ago

This editorial explores findings from the STEP trial conducted in China, which confirmed cardiovascular benefits of intensive systolic blood pressure targets in older adults. It critiques traditional ... 2 days ago

This article highlights recent advances in modeling human cardiac development using organoids. The featured study by Hofbauer et al. presents the creation of cardioids—three-dimensional, self-organi... 2 days ago

This phase 2 randomized trial evaluated the efficacy and safety of milvexian, an oral Factor XIa inhibitor, for preventing venous thromboembolism in 1242 patients undergoing knee arthroplasty. Partici... 2 days ago

This randomized clinical trial compares milrinone and dobutamine in patients with cardiogenic shock. The study enrolled 192 participants, assigning them to either drug to assess outcomes like mortalit... 2 days ago

This perspective article argues against the FDA’s proposed withdrawal of approval for 17 alpha hydroxyprogesterone caproate (17OHP), a drug used to prevent recurrent preterm birth in high risk women... 2 days ago

This perspective article explores the ethical and public health considerations surrounding recommendations to delay pregnancy during public health emergencies, focusing on the COVID-19 pandemic. Drawi... 2 days ago

This case report describes a 30 year old pregnant woman who presented at 34 weeks of gestation with a pruritic rash that progressed to confluent papules and blisters on her abdomen, thorax, and limbs.... 2 days ago

Abdominal aortic aneurysms are defined as having an aortic diameter of more than 3 cm. In the United States, the prevalence is estimated to be 1.4% among individuals aged 50 to 84. Risk factors for de... 2 days ago

This article discusses the clinical implications of mitochondrial replacement techniques, including their use for preventing severe mitochondrial diseases and treating infertility. The procedure, ofte... 2 days ago

This multicenter, randomized, noninferiority trial compared two glucose threshold values for treating asymptomatic moderate hypoglycemia in newborns. The study involved 689 otherwise healthy newborns ... 2 days ago