This article, written from the perspective of a neonatologist, reflects on a newborn’s struggle to breathe in the first moments of life and the systemic challenges in U.S. perinatal care. The physic... 4 weeks ago

IgA nephropathy, once considered a benign condition, is now recognized as the most common glomerulopathy worldwide, often progressing to end-stage kidney disease. Despite decades of symptomatic care, ... 4 weeks ago

An 84-year-old man with a history of melanoma on the right forehead, complicated by in-transit metastases to the scalp, developed blue-gray macules after receiving immunotherapy.Seven months after sta... 4 weeks ago

Tubal ectopic pregnancy occurs when a fertilized egg implants in the fallopian tube, posing a serious risk of rupture and hemorrhage. This condition accounts for approximately 2% of pregnancies in Nor... 4 weeks ago

This clinical problem-solving case discusses a 29-year-old man who presented with fever, chills, and joint pain, revealing an unusual dual diagnosis of secondary syphilis and methicillin-resistant Sta... 4 weeks ago

This editorial examines vascular inflammation in atherothrombosis and assesses whether early anti-inflammatory intervention can improve outcomes in patients with acute myocardial infarction.The articl... 4 weeks ago

This correspondence details the use of tirzepatide, a once-weekly dual GLP-1/GIP agonist, in two patients with congenital generalized lipodystrophy type 1 (AGPAT2 variant). Congenital generalized lipo... 4 weeks ago

Private equity investments in global health care have surged, reaching $446 billion between 2018 and 2022. Historically associated with U.S. health care financialization, private equity has expanded i... 4 weeks ago

This reflective essay explores the complexities of compassion, moral responsibility, and self-awareness in medical practice. The author, a physician, recounts an early morning scene in which a naked w... 4 weeks ago

This article critiques the Cass Review, a report commissioned by England’s National Health Service (NHS) in 2024, which argues that there is insufficient evidence to support gender-affirming care (G... 4 weeks ago

This deeply reflective piece explores the ethical and emotional challenges faced by healthcare providers when caring for difficult patients. The author recounts multiple hospital admissions of Mr. M.,... 4 weeks ago

This article examines the implications of a temporary halt on public communications from the Centers for Disease Control and Prevention (CDC) under the Trump administration in early 2025. The directiv... 4 weeks ago

Spironolactone, a mineralocorticoid receptor antagonist, is established in the treatment of heart failure following myocardial infarction (MI). However, its routine use post-MI remains uncertain.This ... 4 weeks ago

A 17-year-old boy from El Salvador was diagnosed with pleural paragonimiasis after a routine chest radiograph at an immigration clinic revealed a pleural effusion. Despite being asymptomatic, further ... 4 weeks ago

Recent legislative efforts in multiple U.S. states have sought to limit access to gender-affirming care, introducing novel legal tactics that may impact informed consent across other medical areas. Wh... 4 weeks ago

A 29-year-old man with well-controlled HIV infection presented with a painful, whitish discoloration on his tongue for one week. He also reported scrotal ulcers that had resolved over the previous fou... 4 weeks ago

A previously healthy 44-year-old woman presented with mouth ulcers and blistered lips persisting for 11 months, causing pain while eating and unintentional weight loss. She also reported skin blisters... 4 weeks ago

This article examines the challenges of applying standardized communication techniques in medical education and palliative care. The author reflects on a family meeting where a trainee struggled to co... 4 weeks ago

In this deeply personal narrative, Dr. Hannah Kirsch, a neurointensivist and palliative care researcher, recounts her experience as both a physician and daughter during her mother’s terminal illness... 4 weeks ago

Nonacute subdural hematoma (SDH) is a growing concern among aging populations, particularly with increased use of antiplatelet and anticoagulant therapies. Traditional treatments, including glucocorti... 4 weeks ago

The clinical relevance of microvascular inflammation in kidney transplants remains unclear, posing diagnostic and therapeutic challenges. This multicenter cohort study assessed biopsy specimens from 6... 4 weeks ago

Rwanda’s rapid containment of the 2024 Marburg virus disease (MVD) outbreak demonstrated a transformative model for epidemic response, contrasting historical trends. The outbreak began in September ... 4 weeks ago

Rwanda’s rapid containment of the 2024 Marburg virus disease (MVD) outbreak demonstrated a transformative model for epidemic response, contrasting historical trends. The outbreak began in September ... 4 weeks ago

The EMPA-KIDNEY trial previously demonstrated positive cardiorenal effects of empagliflozin, an SGLT2 inhibitor, in patients with chronic kidney disease (CKD). This study assessed whether these benefi... 4 weeks ago

A 46-year-old woman with multiple myeloma presented with hoarseness and a painful sensation while swallowing. She had undergone autologous stem-cell transplantation five years earlier and was receivin... 4 weeks ago

A 35-year-old man with progressive limb weakness, intermittent muscle cramping, fatigue, weight gain, and constipation was diagnosed with hypothyroid myopathy with muscle pseudohypertrophy (Hoffman’... 4 weeks ago

A 55-year-old man with a history of orthotopic liver transplantation developed post-transplantation Kaposi’s sarcoma, which was previously diagnosed in his liver, ventricle, and lymph nodes. A routi... 4 weeks ago

Patients undergoing standard treatment for chronic subdural hematoma have a high risk of treatment failure, with recurrence rates ranging from 5% to 50%. This randomized controlled trial (STEM) examin... 4 weeks ago

Food and nutrition insecurity affects populations globally, with disproportionate harm to those with limited resources. The review highlights its role in malnutrition, communicable and noncommunicable... 4 weeks ago

A 19-year-old man presented with a three-week history of asymptomatic serpiginous eruptions on his neck. As a beach lifeguard in Southern California, he had no history of international travel. Physica... 4 weeks ago

Inflammation plays a key role in adverse cardiovascular events, leading researchers to investigate colchicine as a potential treatment for myocardial infarction. This multicenter, randomized controlle... 4 weeks ago

Patients with IgA nephropathy and severe proteinuria face a high lifetime risk of kidney failure. This phase 3 randomized controlled trial evaluated the efficacy of atrasentan, a selective endothelin ... 4 weeks ago

Chronic kidney disease (CKD) affects 14% of the U.S. population and poses substantial risks for end-stage kidney disease, cardiovascular events, and mortality. Despite therapeutic stagnation, sodium-g... 4 weeks ago

IgA nephropathy is the most prevalent type of glomerulonephritis, leading to progressive kidney damage due to immune complex deposition. The alternative complement pathway plays a central role in dise... 4 weeks ago

Tumor-induced osteomalacia is the most common acquired form of fibroblast growth factor 23-related hypophosphatemic rickets-osteomalacia (FGF23rHR). However, in 27% to 45% of cases, causative tumors r... 4 weeks ago

Antibody-mediated rejection is a major determinant of allograft survival and has evolved significantly since the era of hyperacute rejection. The Banff Classification of Allograft Pathology, first int... 4 weeks ago

A 62-year-old man presented with postprandial abdominal pain worsening over two years, alongside weight loss, nausea, and an irreducible umbilical hernia. While living in Costa Rica, he was diagnosed ... 4 weeks ago

A 30-year-old woman presented with progressive dysesthesia, worsening headache, and confusion following recent travel to Thailand, Japan, and Hawaii. Initially experiencing burning sensations in her f... 4 weeks ago

A 14-year-old adolescent presented with a 12-month history of joint pain, intermittent blurry vision, and severe bifrontal headaches. Symptoms worsened over three weeks despite ibuprofen use, leading ... 4 weeks ago

A 90-year-old man with atrial fibrillation and dementia presented with sudden-onset dyspnea, which began one hour before admission. The patient had not been receiving anticoagulation therapy due to pr... 4 weeks ago