This correspondence describes therapeutic plasma exchange (TPE) as a potential treatment for vaccine-induced immune thrombotic thrombocytopenia (VITT) refractory to first-line therapy. Three patients ... 2 days ago
TTACC, ACTIV-4a, and REMAP-CAP Investigators* (lead authors include: Ewan C. Gol...
Covid-19, therapeutic anticoagulation, heparin, noncritically ill patients, organ support-free days, thromboprophylaxis, randomized trial, D-dimer, bleeding risk, ICU-level support
This multicenter randomized trial assessed whether therapeutic-dose heparin improves outcomes in hospitalized noncritically ill Covid-19 patients. A total of 2219 participants across 9 countries were ... 2 days ago
This international multiplatform randomized trial investigated whether therapeutic-dose heparin improves outcomes in critically ill patients with Covid-19. A total of 1098 patients were randomized to ... 2 days ago
This editorial emphasizes the importance of contextualizing vaccine safety data during a pandemic. It revisits the 1976 swine flu vaccination program, highlighting how early Guillain-Barré syndrome r... 2 days ago
This editorial explores evolving strategies for post–percutaneous coronary intervention (PCI) antithrombotic therapy, especially in patients with high bleeding risk. It highlights the Valgimigli et ... 2 days ago
This editorial reviews evolving evidence on anticoagulation strategies for hospitalized Covid-19 patients, emphasizing the role of heparin. Patients with moderate illness appear to benefit from therap... 2 days ago
This editorial reviews findings from the EMPEROR-Preserved trial, which examined the effects of SGLT2 inhibitors—originally developed for type 2 diabetes—on patients with heart failure with preser... 2 days ago
This observational study assessed the safety profile of the BNT162b2 mRNA Covid-19 vaccine across a nationwide cohort in Israel. Using matched controls, researchers evaluated 42-day post-vaccination r... 2 days ago
This editorial discusses the Vitamin D Antenatal Asthma Reduction Trial (VDAART), which investigated whether high-dose vitamin D supplementation (4400 IU/day) during pregnancy prevents childhood ... 2 days ago
myocarditis, Covid-19 vaccine, BNT162b2, mRNA vaccine, young males, vaccine hesitancy, diagnostic criteria, endomyocardial biopsy, public health, editorial
This editorial discusses myocarditis as a rare but notable side effect associated with the BNT162b2 mRNA Covid-19 vaccine, particularly in young males. Drawing on two retrospective studies from Israel... 2 days ago
Isaac Manyonda, Ph.D., Anna-Maria Belli, F.R.C.R., Mary-Ann Lumsden, M.D., Jonat...
Uterine fibroids, myomectomy, uterine-artery embolization (UAE), quality of life, UFS-QOL, hysterectomy avoidance, randomized trial, FEMME study
This multicenter randomized trial compared uterine artery embolization (UAE) and myomectomy in 254 women with symptomatic uterine fibroids who wished to avoid hysterectomy. At 2 ye... 2 days ago
pollution, cardiovascular disease, air pollution, PM₂.₅, toxic metals, endocrine disruptors, fossil fuels, hypertension, diabetes, global health
This comprehensive review explores the relationship between pollution and cardiovascular disease, emphasizing pollution as a major but often neglected risk factor. It details how air poll... 2 days ago
Desmond Sutton, M.D., Karin Fuchs, M.D., M.H.A., Mary D’Alton, M.D., Dena Goffman, M.D.
This correspondence reports findings from universal SARS-CoV-2 testing implemented for 215 pregnant women admitted for delivery at two New York City hospitals during the early Covid-19 pande... 2 days ago
POCUS, bedside ultrasound, handheld imaging, diagnostic accuracy, cardiac arrest, procedural guidance, AI in ultrasound, clinical training, consultative ultrasonography, cost-effectiveness
This review article discusses point-of-care ultrasonography (POCUS), which refers to ultrasonographic imaging performed and interpreted by the treating clinician at the bedside. It highli... 2 days ago
This Images in Clinical Medicine entry reports a rare case of complex umbilical cord knotting in monochorionic, monoamniotic twins delivered via cesarean section at 32 weeks of ges... 2 days ago
infective endocarditis, intravenous antibiotics, oral therapy, Staphylococcus aureus, POET trial, drug use, treatment adherence, patient-centered care, outpatient therapy, antimicrobial management
This interactive editorial explores antibiotic treatment strategies for methicillin-sensitive Staphylococcus aureus endocarditis in a patient with active intravenous drug use. Two expert viewpoints ar... 2 days ago
This correspondence investigates the potential immunological link between SARS-CoV-2 vaccination and vaccine-induced immune thrombotic thrombocytopenia (VITT), focusing on antibody responses. Research... 2 days ago
This multicenter randomized trial evaluated the effect of immediate coronary angiography versus delayed/selective angiography in 554 patients with resuscitated out-of-hospital cardiac arrest of possib... 2 days ago
This Images in Clinical Medicine entry describes a case of twin anemia polycythemia sequence (TAPS) in monochorionic, diamniotic twins born at 31 weeks of gestation. The first twin... 2 days ago
Guy Witberg, Noam Barda, Sara Hoss, Ilan Richter, Maya Wiessman, Yaron Aviv, Tzl...
myocarditis, BNT162b2, mRNA vaccine, Covid-19 vaccination, Israel, Clalit Health Services, cardiac inflammation, vaccine surveillance, adverse events, young males
This retrospective cohort study evaluated myocarditis incidence following administration of the BNT162b2 mRNA Covid-19 vaccine within Israel’s largest healthcare organization. Of 2.56 million vaccin... 2 days ago
This correspondence reports two adult cases of histologically confirmed myocarditis occurring within 2 weeks of Covid-19 mRNA vaccination. Patient 1, a 45-year-old woman, developed severe left ventric... 2 days ago
This perspective article examines the implications of Idaho’s Fairness in Women’s Sports Act, which bars transgender girls and women from participating in female athletic teams. The law, chal... 2 days ago
This retrospective cohort study from Israel examined the incidence of myocarditis following the BNT162b2 mRNA Covid-19 vaccine. Active surveillance was conducted between December 2020 and May 2021. Of... 2 days ago
Khalil G. Ghanem, M.D., Ph.D., Sanjay Ram, M.B., B.S., Peter A. Rice, M.D.
Syphilis, Treponema pallidum, epidemiology, diagnosis, treatment, penicillin, congenital syphilis, neurosyphilis, public health
Syphilis, caused by Treponema pallidum, has resurged in the United States, reaching levels not seen in over two decades. This review explores the epidemiology, clinical manifestations, diagnostic... 2 days ago
Lindsey A. George, Paul E. Monahan, M. Elaine Eyster, Spencer K. Sullivan, Marga...
hemophilia A, AAV gene therapy, SPK-8011, factor VIII expression, bleeding reduction, liver-targeted therapy, immune response, clinical trial, hepatocyte expression
This phase 1–2 clinical trial investigated SPK-8011, an adeno-associated viral (AAV) vector designed to promote hepatocyte expression of factor VIII in adult men with hemophilia A. Amon... 2 days ago
This study investigated the long-term effects of prenatal vitamin D supplementation on asthma and recurrent wheeze in children through age 6. A randomized, double-blind trial compared high dose (4400 ... 2 days ago
Affordable Care Act (ACA), Supreme Court, Ruth Bader Ginsburg, health law, reproductive rights, equality, individual mandate, California v. Texas
This perspective article examines the potential consequences of a Supreme Court challenge to the Affordable Care Act (ACA) in California v. Texas, particularly in the absence of Justice Ruth Bade... 2 days ago
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants. This randomized, observer-blind, placebo-controlled phase 3 trial evaluated the efficacy o... 2 days ago
Bacterial vaginosis (BV) affects 15–50% of women of reproductive age, with high recurrence rates after antibiotic treatment. This randomized, double-blind, placebo controlled phase 2b trial evaluate... 2 days ago
This editorial explores findings from the STEP trial conducted in China, which confirmed cardiovascular benefits of intensive systolic blood pressure targets in older adults. It critiques traditional ... 2 days ago
cardiac organoids, cardioids, congenital heart defects, stem cells, myocardial development, epicardium, endocardium, hypoplastic left heart syndrome, cardiac injury, regenerative medicine
This article highlights recent advances in modeling human cardiac development using organoids. The featured study by Hofbauer et al. presents the creation of cardioids—three-dimensional, self-organi... 2 days ago
This phase 2 randomized trial evaluated the efficacy and safety of milvexian, an oral Factor XIa inhibitor, for preventing venous thromboembolism in 1242 patients undergoing knee arthroplasty. Partici... 2 days ago
This randomized clinical trial compares milrinone and dobutamine in patients with cardiogenic shock. The study enrolled 192 participants, assigning them to either drug to assess outcomes like mortalit... 2 days ago
Michael F. Greene, Mark A. Klebanoff, David Harrington
Preterm birth prevention, 17OHP, 17 alpha-hydroxyprogesterone caproate, FDA approval, racial disparities, maternal-fetal medicine
This perspective article argues against the FDA’s proposed withdrawal of approval for 17 alpha hydroxyprogesterone caproate (17OHP), a drug used to prevent recurrent preterm birth in high risk women... 2 days ago
Sonja A. Rasmussen, Anne Drapkin Lyerly, Denise J. Jamieson
COVID-19, pregnancy delay, public health recommendations, reproductive autonomy, ethics, Zika virus, H1N1 influenza, maternal health, risk mitigation
This perspective article explores the ethical and public health considerations surrounding recommendations to delay pregnancy during public health emergencies, focusing on the COVID-19 pandemic. Drawi... 2 days ago
This case report describes a 30 year old pregnant woman who presented at 34 weeks of gestation with a pruritic rash that progressed to confluent papules and blisters on her abdomen, thorax, and limbs.... 2 days ago
Abdominal aortic aneurysms are defined as having an aortic diameter of more than 3 cm. In the United States, the prevalence is estimated to be 1.4% among individuals aged 50 to 84. Risk factors for de... 2 days ago
Mitochondrial replacement, mitochondrial DNA (mtDNA), infertility treatment, three-parent babies, pronuclear transfer, spindle transfer, genetic disorders, ethics in medicine
This article discusses the clinical implications of mitochondrial replacement techniques, including their use for preventing severe mitochondrial diseases and treating infertility. The procedure, ofte... 2 days ago
This multicenter, randomized, noninferiority trial compared two glucose threshold values for treating asymptomatic moderate hypoglycemia in newborns. The study involved 689 otherwise healthy newborns ... 2 days ago