Background: Anaemia in pregnancy has rippling health effects on mothers and babies. Iron supplementation during pregnancy is essential in reversing the situation. The study was carried out to

assess factors influencing compliance with iron supplementation among pregnant women in the Wa East District of Ghana.

Methods: A community based descriptive cross-sectional survey design was adopted to study pregnant women aged 15 to 49 years, who were residents of the area and were within a gestational period of 36 weeks. Simple random sampling was used to derive the sample.

Results: The mean age of respondents was 28.5 (±7.5) with a minimum age of 16 years and a maximum age of 47 years. Fifty-four-point one percent (54.1%) of the respondents had their HB level below 10.5 g/dl. Forty-seven-point six percent (47.6%, 170/357) of the study respondents comply with iron supplement. Factors that were associated with the compliance of iron supplement intake were; side effect, counselling, forgetfulness, family support, fed up and knowledge on IFA and anaemia

Conclusion: This study found a high prevalence of anemia among pregnant women suggesting more work needs to be done to reduce it to acceptable limits. Also, compliance rate with iron supplement intake among pregnant women 15-47 years was found to be low. Predictors of compliance could be exploited to address the high prevalence of anaemia.