Male partner involvement in antenatal care is crucial for improving maternal and child health outcomes. Traditionally, antenatal care has been centered around the pregnant woman, excluding men. However, recent studies have highlighted the benefits of involving male partners in antenatal care, including improved maternal health outcomes, reduced risk of preterm birth and low birth weight, and better child development. Barriers to male involvement include lack of education, fear of not knowing what to do or say, and societal expectations. Healthcare providers can promote male involvement through education and support, and various strategies are effective in increasing male participation. The main objective of the study is to assess male partner involvement in antenatal care in the East Gonja Municipality, Ghana. The study employed a cross-sectional design with a quantitative approach to investigate male partner involvement in antenatal care. A sample of 330 pregnant women aged 18-49 years were recruited from an Antenatal Care unit at a hospital. Data was collected using a structured questionnaire, which included demographic information, socio-cultural and economic factors, and questions about male partner involvement in antenatal care. SPSS version 25 was used for the analysis. Descriptive statistics were used to analyze the data, and chi-square tests and binary logistic regression analysis were used to examine the relationships between variables. The study's methodology was approved by the Navrongo Health Research Centre Institutional Review Board. The study found that only 23% of men attended antenatal care with their partners, citing various reasons such as cultural and societal norms, lack of awareness, and stigma. Economic factors like financial constraints, work-related barriers, and economic responsibilities also contributed to male disengagement. The study found significant associations between male involvement in antenatal care and educational level (42.376, P<0.001), religion (9.873, P<0.020), occupation (14.895, P<0.002), and marital status (8.374, P<0.039). Educational level was the only variable that had a significant relationship with male involvement and antenatal attendance in the binary logistic regression analysis. The study highlights the importance of addressing cultural, social, and economic factors that contribute to male disengagement from antenatal care, emphasizing the need for education, awareness-raising initiatives, and policy changes to promote male involvement in pregnancy and childbirth.