Introduction: Job satisfaction is positively and mutually related to life satisfaction. Job satisfaction is affected by employee's desire to use their skills and abilities. Employee job satisfaction results in positive behavioural outcomes at work. High job satisfaction enables employees to satisfy customers/patients whiles creating customer experience at work. Satisfaction in the workplace plays a dominant role in eliciting positive work behaviour in the Ghanaian healthcare setting.

Methods: The current study was conducted to assess factors influencing job satisfaction among nursing staff in the Akatsi South Municipal Hospital, using an institution based descriptive cross-sectional survey research design. The study was conducted among 290 nursing staff working selected using convenience sampling method. A questionnaire was used for data collection. The collected data was analyzed using descriptive statistics such as percentages and frequencies and inferential statistics (ANOVA and chi square test).

Results: The study revealed a substantial correlation between team dynamics and job satisfaction, presenting a notable disparity. An association was identified between the work environment and the level of job satisfaction among nurses. There exists a positive correlation between a fair work environment and heightened levels of job satisfaction, whereas an unfair work environment is linked to diminished levels of satisfaction. The presence of career advancement prospects has been identified as a significant factor influencing the level of job satisfaction among nurses. There was a significant correlation between the availability of sufficient career advancement prospects and increased levels of job satisfaction among nurses.

Conclusion: Healthcare organizations ought to prioritize the establishment of opportunities for professional growth to augment nurses' job happiness and general welfare. The study may be useful in minimizing high attrition levels, which may be caused by low levels of job satisfaction in the Ghanaian healthcare system.  The study of job satisfaction has relevance to nursing from economic, humanitarian, and professional perspectives.