The World Health Organization (WHO) reports that neglected tropical diseases (NTDs) represent a diverse group of 20 communicable diseases that occur in tropical and subtropical conditions in 149 countries and these affects more than 1 billion people and cost developing countries billions of dollars annually. The general objective of the study is to ascertain the health-seeking behaviour for skin-related NTDs in the Atwima Mponua District of the Ashanti Region of Ghana. A research design is a procedural plan that is adopted in a study to answer questions validly, objectively, accurately and economically. The research design was a descriptive cross-sectional using quantitative data collection tools. The research tool was filled by serial number and the principal Investigator did entry using the Statistical Package for Social Sciences (SPSS) version 21.0 software. The results show that most variables under stigmatization were not associated with health seeking behaviour. Those who indicated that Community has less respect for me because of the condition showed significant association (X2 = 1.6, p=0.040), however was not significant at the Crude odds ratio COR (1.1(0.3-6.1) O=0.641). The study recommended that Intensify counselling and support services for both old and new cases of skin-related NTDs in order to support them to stay positive amidst stigma and discrimination.