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Conjunctival Papilloma

Article Number: SIS362450AI050825
5th August, 2025
Author(s):
Zehao Liu, Ying Lin
Abstract:

A 26-year-old man presented with a 2-month history of a painless, reddish growth on the left eye. Examination showed a sessile conjunctival mass with visible vascular fronds and an episcleral feeder vessel, accompanied by mild hyperemia. Surgical excision with cryotherapy was performed. Histology revealed epithelial hyperplasia with fibrovascular cores, confirming conjunctival papilloma, a common benign tumor associated with human papillomavirus. The patient had not been vaccinated against HPV. No recurrence was observed at 3-month follow-up. Characteristic “hairpin” vessel loops aid in distinguishing papilloma from malignant lesions; treatment options include interferon alfa-2b, surgery with cryotherapy, or both

Keywords:
conjunctival papilloma benign ocular tumor episcleral feeder vessel hairpin vessel loops squamous epithelial hyperplasia fibrovascular tissue HPV-associated lesions cryotherapy interferon alfa-2b ophthalmology young adult eye growths
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