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Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
Article Number: SIS137082AI201222
20th December, 2022
Author(s):
Yüksel KAYA1 , Ayşegül ÇEBİ2, Nihat SÖYLEMEZ1 , Halit DEMİR3 , Hamit Hakan ALP4 , Ebubekir BAKAN4
Abstract:
The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and
oxidative DNA damage was investigated.
Seventy-seven patients with CAD and 44 healthy individuals as control were included in this
study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2
’
-deoxyguanosine/
deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD
by colorimetric approach in blood samples obtained from patients with CAD were unraveled.
8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level
in serum of CAD patients compared to control group. The SOD activity was observed in
stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in
patients with CAD than the controls.
The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and
GPX activity, while the significant negative correlation was seemed between the ratio of
8-OHdG/dG and ubiquinol-10/ ubiquinone-10 as well as MDA levels and ubiquinol-10/
ubiquinone-10 ratio.
We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative
stress in DNA may play an important role in the pathogenesis of coronary artery disease.