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Cytomegalovirus Retinitis
Nicolas Kitic, M.D, ...
Cytomegalovirus retinitis, HIV, immune reconstitution inflammatory syndrome, retinal necrosis, ophthalmology, antiretroviral therapy, viral infection, visual impairment, ganciclovir, foscarnet.

Cytomegalovirus (CMV) retinitis is a vision-threatening opportunistic infection commonly observed in... 1 month ago

Coordinating Multidisciplinary Care — Improving ...
Nicola Napoli, M.D.,...
osteoporosis, fragility fractures, hip fractures, fracture liaison services, bone health, secondary fracture prevention, patient outcomes, healthcare systems, multidisciplinary care, mortality rates

Osteoporosis-related fractures are a significant health concern, leading to disability and increased... 1 month ago

Congenital Spinal Meningocele
Tariq Parker, M.D.,...
congenital spinal meningocele, neural-tube defect, lumbosacral anomaly, antenatal ultrasound, cesarean section, cerebrospinal fluid, meninges herniation, neonatal surgery

A newborn boy was admitted to the neonatal intensive care unit for management of an open lumbosacral... 1 month ago

Chronic Myeloid Leukemia with Hyperleukocytosis
Bashir A. Bashir, Ph...
chronic myeloid leukemia, hyperleukocytosis, BCR-ABL1 fusion gene, hematologic malignancy, leukocytosis, lymphadenopathy, hepatosplenomegaly, molecular testing, war-related displacement, multiorgan failure

A 64-year-old woman presented with fatigue, fever, and cough, following displacement due to conflict... 1 month ago

Challenges to the Future of a Robust Physician Wor...
Rochelle P. Walensky...
physician shortage, workforce crisis, rural health disparities, graduate medical education (GME), Health Professional Shortage Areas (HPSAs), medical school debt, primary care, Silver Tsunami, Flexner Report

The United States faces a looming physician workforce crisis, exacerbated by geographic disparities,... 1 month ago

Cervical Cancer
Krishnansu S. Tewari...
cervical cancer, human papillomavirus (HPV), HPV vaccination, chemoradiation therapy, pembrolizumab, bevacizumab, radical hysterectomy

Cervical cancer remains a significant global health burden, with an estimated 604,127 new cases and ... 1 month ago

Bladder Stone
Zihao Li, B.Med.; Zh...
bladder stone, neurogenic bladder, indwelling catheter, urinary stasis, holmium laser lithotripsy, Escherichia coli, Morganella morganii, hematuria, urinary tract infection, urolithiasis

A 72-year-old woman with a 30-year history of high thoracic paraplegia and neurogenic bladder presen... 1 month ago

Case 5-2025: A 30-Year-Old Woman with Headache a...
Joseph Zunt, M.D., M...
eosinophilic meningitis, Angiostrongylus cantonensis, parasitic infection, dysesthesia, headache, returning traveler, cerebrospinal fluid (CSF), nucleic acid amplification testing (NAAT), albendazole, prednisone, neuroinfectious disease, travel medicine

A 30-year-old woman presented with an 8-day history of progressive dysesthesia, headache, and confus... 1 month ago

Argyria
Tin Yan Lee, M.B., C...
Argyria, silver toxicity, skin pigmentation, systemic exposure, dermatopathology, toxicology

Background:An 84-year-old man with benign prostatic hyperplasia was admitted for acute kidney injury... 1 month ago

APOL1 Kidney Disease Variants — Information fro...
Simone Sanna-Cherchi...
APOL1, chronic kidney disease, focal segmental glomerulosclerosis, West Africa, genetic variants, Trypanosoma brucei, genotype, ethnolinguistic groups

Background:Chronic kidney disease (CKD) disproportionately affects populations of African ancestry, ... 1 month ago

APOL1 Bi- and Monoallelic Variants and Chronic Kid...
R.A. Gbadegesin, I. ...
APOL1, chronic kidney disease, West Africans, genetic variants, focal segmental glomerulosclerosis, case-control study

Background: Apolipoprotein L1 gene (APOL1) variants are risk factors for chronic kidney disease (CKD... 2 months ago

A Randomized Trial of Drug Route in Out-of-Hospit...
K. Couper, C. Ji, C....
out-of-hospital cardiac arrest, intraosseous, intravenous, vascular access, epinephrine, randomized trial, survival, neurologic outcome

Background: In patients with out-of-hospital cardiac arrest, the effectiveness of drugs such as epin... 2 months ago

A Comparison of Peripherally Inserted Central Cath...
Amanda J. Ullman, De...
peripherally inserted central catheter, PICC, hydrophobic, chlorhexidine, polyurethane, device failure, infectious complications, thrombotic complications, randomized controlled trial

BACKGROUNDNew catheter materials for peripherally inserted central catheters (PICCs) may reduce the ... 2 months ago

Case 4-2025: A 41-Year-Old Man with Syncope, Ankle...
Daniel Restrepo, Sad...
Löfgren’s syndrome, Sarcoidosis, Bilateral hilar lymphadenopathy, Erythema nodosum, Inflammatory arthritis, Syncope, Glucocorticoids, Cardiac sarcoidosis, Pulmonary nodules, Autoimmune disease.

A 41-year-old man with a history of coronary artery disease presented with syncope, bilateral ankle ... 2 months ago

Case 2-2025: A 21-Year-Old Man with Loss of Consci...
Eric F. Shappell, Br...
Posterior reversible encephalopathy syndrome, Sickle cell disease, Seizure, Vaso-occlusive crisis, Cerebral fat embolism, MRI, Red-cell exchange, Hypertension, Microhemorrhages, Neurologic complications.

A 21-year-old man with sickle cell disease presented with loss of consciousness and a fall, followed... 2 months ago

Case 1-2025: A 35-Year-Old Woman with Shortness of...
Jessica S. Tangren, ...
Focal segmental glomerulosclerosis, Nephrotic syndrome, Postpartum complications, Preeclampsia, Proteinuria, Hypoalbuminemia, Kidney biopsy, Hypertension, Edema, Glomerular disease, Immunosuppression, Collapsing glomerulopathy.

A 35-year-old woman presented with postpartum shortness of breath and progressive leg edema. Initial... 2 months ago

What’s Next for Nicotine? The Coming Legal and P...
Patricia J. Zettler ...
Nicotine reduction, FDA regulation, tobacco control, addiction, public health policy, legal challenges

BACKGROUNDOn January 16, 2025, the FDA proposed limiting nicotine levels in cigarettes to 0.70 mg pe... 2 months ago

The Definition of Heart Failure
Jason Gurney
Heart failure, terminology, patient experience, stigma, chronic disease, renaming

BACKGROUNDHeart failure is a major public health problem, affecting more than 64 million people (1 t... 2 months ago

BPROAD — End of the Road for Debate on Systoli...
Shuchi Anand, M.D., ...
Systolic blood pressure, type 2 diabetes, hypertension, cardiovascular risk, intensive therapy, ACCORD BP, SPRINT trial

BACKGROUNDElevated blood pressure mediates much of the organ toxicity affecting persons with type 2 ... 2 months ago

Sotatercept in Patients with Pulmonary Arterial Hy...
Marc Humbert et al. ...
Sotatercept, pulmonary arterial hypertension, WHO functional class, REVEAL Lite 2, composite endpoint, hospitalization, mortality

BACKGROUNDSotatercept improves exercise capacity and delays the time to clinical worsening in patien... 2 months ago

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