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Taking a BAT to the Chains of Diabetes
Zoltan Arany
Brown adipose tissue (BAT), branched-chain amino acids (BCAAs), insulin resistance, diabetes, thermogenesis, SLC25A44, metabolic syndrome

This article explores the link between elevated branched chain amino acids (BCAAs) and insulin resis... 3 months ago

Stomaching Drug Delivery
David J. Brayden, Al...
Oral drug delivery, macromolecules, gastric device, SOMA, insulin delivery, permeation enhancers, drug-device combinations

This article discusses innovative approaches to overcoming the challenges of oral delivery for macro... 3 months ago

Specifying the Pancreatic Islet through Biomechani...
Ondine Cleaver
Pancreatic islet, biomechanical forces, YAP1, PDX1, endocrine differentiation, extracellular matrix, diabetes

This article explores the role of biomechanical forces in determining the fate of pancreatic progeni... 3 months ago

Six-Month Randomized, Multicenter Trial of Closed...
S.A. Brown, B.P. Kov...
losed-loop system, type 1 diabetes, artificial pancreas, glycemic control, insulin delivery, continuous glucose monitoring

This 6 month randomized, multicenter trial evaluated the efficacy and safety of a closed loop insuli... 3 months ago

Safety and Efficacy of Bempedoic Acid to Reduce LD...
Kausik K. Ray, Harol...
Bempedoic acid, LDL cholesterol, hypercholesterolemia, statin therapy, cardiovascular disease, ATP citrate lyase inhibitor

This 52 week randomized, controlled trial evaluated the safety and efficacy of bempedoic acid in red... 3 months ago

Effect of a Reduced PCV10 Dose Schedule on Pneumoc...
Lay-Myint Yoshida, M...
PCV10 vaccine, pneumococcal carriage, Vietnam, reduced dose schedule, noninferiority trial, catch-up vaccination, Streptococcus pneumoniae, 1p+1 regimen, vaccine-serotype carriage, serotype 6A, cluster randomization, cost-effective immunization

This cluster-randomized trial assessed whether a reduced schedule of the 10-valent pneumococcal conj... 3 months ago

Ebola Outbreak Response in the DRC with rVSV-ZEBOV...
Jean-Jacques Muyembe...
Ebola virus disease (EVD), ring vaccination, rVSV-ZEBOV-GP vaccine, Democratic Republic of Congo, outbreak response, vaccine efficacy, public health intervention, case isolation, cluster trial, contacts-of-contacts

This study evaluates the efficacy of ring vaccination using the rVSV-ZEBOV-GP vaccine during the 201... 3 months ago

Disseminated Coccidioidomycosis
Atif S. Siddiqui, Ja...
coccidioidomycosis, Coccidioides immitis, fungal infection, disseminated disease, fluconazole treatment, pulmonary cavitation, supraclavicular abscess, Grocott’s methenamine silver staining

A 60-year-old man with hypertension presented with hemoptysis and painful cervical masses. Imaging r... 3 months ago

Pituitary Hyperplasia from Primary Hypothyroidism
K.S. Shivaprasad, Ko...
Pituitary hyperplasia, primary hypothyroidism, thyrotropin, levothyroxine, magnetic resonance imaging

A 10 yearold girl presented with headaches and poor growth, accompanied by clinical findings of dry ... 3 months ago

Déjà Vu All Over Again — Refusing to Learn the...
Michael S. Sinha, We...
Covid-19 pandemic, H5N1 influenza, pandemic preparedness, revisionism, public health authority, antivaccine sentiment, surveillance failure, legal constraints, Chevron doctrine, major questions doctrine

This Perspective critiques the U.S. government's early response to emerging H5N1 influenza outbreaks... 3 months ago

Pheochromocytoma and Paraganglioma
Hartmut P.H. Neumann...
Pheochromocytoma, paraganglioma, catecholamines, genetic mutations, adrenal tumors, diagnosis, treatment

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors that arise from chromaffin cells... 3 months ago

Cryoglobulinemia — One Name for Two Diseases
Patrice Cacoub, Math...
cryoglobulinemia, type I cryoglobulinemia, mixed cryoglobulinemia, monoclonal gammopathy, vasculitis, complement-mediated immune complex, hepatitis C virus (HCV), Sjögren's syndrome, lupus, hyperviscosity syndrome

This comprehensive review redefines cryoglobulinemia as two distinct clinical entities: type I, a hy... 3 months ago

Creeping toward Effective Antiviral Agents for RSV...
Edward E. Walsh
RSV, ziresovir, fusion inhibitor, bronchiolitis score, hospitalized infants, antiviral therapy, maternal vaccination, monoclonal antibodies, nasal viral load, drug resistance, symptom onset timing, emergency department management

This editorial reviews a phase 3 trial of ziresovir—a fusion inhibitor—for infants hospitalized ... 3 months ago

Conjunctival Papilloma
Zehao Liu, Ying Lin
conjunctival papilloma, benign ocular tumor, episcleral feeder vessel, hairpin vessel loops, squamous epithelial hyperplasia, fibrovascular tissue, HPV-associated lesions, cryotherapy, interferon alfa-2b, ophthalmology, young adult eye growths

A 26-year-old man presented with a 2-month history of a painless, reddish growth on the left eye. Ex... 3 months ago

Congenital Syphilis
Simone S. Schueller,...
congenital syphilis, hepatomegaly, periostitis, celery stalk appearance, Wimberger sign, Treponema pallidum, thrombocytopenia, elevated alkaline phosphatase, RPR test, treponemal-antibody absorption

A preterm male infant born at 31 weeks’ gestation via cesarean section for fetal distress was note... 3 months ago

Combination Therapy for Chronic HBV Infection
Harry L.A. Janssen, ...
xalnesiran, functional cure, chronic HBV infection, RNA interference, pegylated interferon alfa-2a, ruzotolimod, siRNA therapy, HBV surface antigen (HBsAg), immune exhaustion, hepatocellular carcinoma

This editorial contextualizes new trial findings on xalnesiran, an siRNA targeting HBV surface antig... 3 months ago

Collective Trauma and Commemoration — A Moment o...
George J. Makari, Ri...
Covid-19 pandemic, collective trauma, chronic stress, mourning, mental health, pandemic grief, marginalized communities, public commemoration, neurobiologic impact, social psychiatry, secular rituals

This essay explores the psychological aftermath of the Covid-19 pandemic through the lens of collect... 3 months ago

Chlamydial Proctitis
Kevin D. He, Judith ...
chlamydial proctitis, rectal ulceration, CT imaging, flexible sigmoidoscopy, Chlamydia trachomatis, nucleic acid amplification test, HIV co-infection, CD4 count, viral load, STI screening, antiretroviral therapy

A 26-year-old man presented with a week of fevers and bloody stools following condomless receptive a... 3 months ago

Chest Radiography for Presumed Pneumonia in Childr...
Julie R. Barzilay, M...
pediatric pneumonia, empirical antibiotics, chest radiography, diagnostic uncertainty, pneumonia risk score, febrile respiratory illness, viral versus bacterial infection, antibiotic stewardship, parental anxiety, outpatient management

This interactive case discussion evaluates whether empirical antibiotics or chest radiography should... 3 months ago

Celebrating Public Health
Eric J. Rubin
Lasker-Bloomberg Public Service Award, public health recognition, Abdool Karim, HIV prevention, CAPRISA 004, tenofovir gel, tuberculosis co-infection, pandemic response, SARS-CoV-2 variant

This essay honors the 2024 Lasker-Bloomberg Public Service Award recipients, Drs. Quarraisha and Sal... 3 months ago

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