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Long-Term Complications in Youth-Onset Type 2 Diab...
Petter Bjornstad, Ki...
Youth-Onset Type 2 Diabetes, Long-Term Complications, Microvascular Complications, Hypertension, Dyslipidemia, Diabetic Kidney Disease, Nerve Disease, Retinal Disease

BACKGROUND: The prevalence of type 2 diabetes in youth is increasing, but little is known regarding ... 6 days ago

June Medical Services v. Russo — A Threat to Phy...
Joanne D. Rosen, J.D...
Abortion regulations, physician standing, June Medical Services v. Russo, Supreme Court, admitting-privileges requirement, reproductive rights, legal precedent

This perspective examines the U.S. Supreme Court’s 2020 decision in June Medical Services v. ... 6 days ago

HPV Vaccination and the Risk of Invasive Cervical ...
Jiayao Lei, Ph.D., ...
HPV vaccination, quadrivalent vaccine, cervical cancer, population-based study, Sweden, cancer prevention, human papillomavirus

This nationwide Swedish cohort study evaluated the association between quadrivalent HPV vaccination ... 6 days ago

Imaging in Coronary Artery Disease Risk Stratifica...
Siri R. Kadire, M.D....
coronary artery disease, risk stratification, myocardial perfusion imaging, CT angiography, high-sensitivity troponin, SCOT-HEART trial, FFR-CT, acute chest pain, ischemia, cardiac imaging

This Clinical Decisions article presents a 58-year-old woman with epigastric pain, shoulder and jaw ... 6 days ago

Hospital Mergers and Conscience-Based Objections â...
Ian D. Wolfe, Ph.D....
Hospital mergers, Catholic hospitals, conscience-based objections, patient access, healthcare consolidation, religious restrictions, institutional ethics

This perspective article examines the growing influence of Catholic hospital mergers in the U.S. hea... 6 days ago

Immune and Genome Engineering as the Future of Tra...
Jennifer Elisseeff, ...
regenerative medicine, genome engineering, immune engineering, extracellular matrix, xenotransplantation, CRISPR-Cas9, regulatory T cells, exogenesis, organ scaffolds, stem cell

This review article explores the convergence of immune engineering and genome editing in advancing r... 6 days ago

Hormone Therapy for Postmenopausal Women
JoAnn V. Pinkerton,...
Menopause, hormone therapy, vasomotor symptoms, genitourinary syndrome, cardiovascular risk, breast cancer, nonhormonal treatments

This clinical review examines the benefits and risks of hormone therapy for postmenopausal women, fo... 6 days ago

Heparin Resistance — Clinical Perspectives and M...
Jerrold H. Levy, Jea...
heparin resistance, unfractionated heparin, antithrombin, COVID-19, factor Xa, aPTT, anti-factor Xa assay, thrombosis, bivalirudin, argatroban

This review article outlines the mechanisms, diagnosis, and management strategies for heparin resist... 6 days ago

Higher or Lower Hemoglobin Transfusion Thresholds ...
Haresh Kirpalani, B...
Preterm infants, hemoglobin thresholds, red-cell transfusions, neurodevelopmental impairment, extremely low birth weight infants, neonatal intensive care

Limited data suggest that higher hemoglobin thresholds for red cell transfusions may reduce the risk... 6 days ago

Gene Editing — A Cure for Transthyretin Amyloido...
Mathew S. Maurer, M....
transthyretin amyloidosis, CRISPR-Cas9, NTLA-2001, gene editing, in vivo therapy, lipid nanoparticles, polyneuropathy, cardiomyopathy, hereditary disease, ATTR treatment

This editorial explores the therapeutic potential of in vivo CRISPR-Cas9 gene editing for transthyre... 6 days ago

Health Coverage and Care for Transgender People â€...
Daphna Stroumsa, Ann...
Transgender health, gender-affirming care, health insurance, LGBTQ+ rights, Affordable Care Act, Bostock v. Clayton County

This perspective examines the evolving landscape of health coverage and care for transgender individ... 6 days ago

Empagliflozin in Heart Failure with a Preserved Ej...
Hans-Peter Brunner-L...
heart failure, SGLT2 inhibitor, EMPEROR-Preserved, hospitalization, cardiovascular death,

This randomized, double-blind trial (EMPEROR-Preserved) assessed empagliflozin versus placebo in 598... 6 days ago

Genomic Insights into Stillbirth
Monica H. Wojcik
Stillbirth, genomic sequencing, exome sequencing, fetal loss, genetic diagnosis, perinatal outcomes

This editorial examines the role of genomic sequencing in understanding the genetic causes of stillb... 6 days ago

Fallopian Tube Torsion
L.M. Lim, Harvard Z....
Fallopian tube torsion, adnexal torsion, hydrosalpinx, laparoscopy, salpingectomy

A 19 year old woman presented with acute abdominal pain and was diagnosed with left fallopian tube t... 6 days ago

Empagliflozin and Major Renal Outcomes in Heart Fa...
Milton Packer, Javed...
empagliflozin, heart failure, EMPEROR trial, ejection fraction, renal outcomes, chronic kidney disease, pooled analysis, SGLT2 inhibitors, eGFR decline, renal replacement therapy

This correspondence describes a pooled patient-level analysis of the EMPEROR-Reduced and EMPEROR-Pre... 6 days ago

Effect of Salt Substitution on Cardiovascular Even...
Bruce Neal, Yangfeng...
salt substitute, stroke prevention, cardiovascular mortality, potassium chloride, sodium reduction, hypertension, rural health, SSaSS trial, hyperkalemia, cluster randomized trial

This large cluster-randomized trial (SSaSS) enrolled 20,995 adults from 600 rural Chinese villages p... 6 days ago

Exome Sequencing for Prenatal Diagnosis in Nonimmu...
Teresa N. Sparks, Bi...
Exome sequencing, prenatal diagnosis, nonimmune hydrops fetalis, genetic disorders, RASopathies, inborn errors of metabolism

his study evaluated the diagnostic yield of exome sequencing in 127 consecutive cases of unexplained... 6 days ago

Dual Antiplatelet Therapy after PCI in Patients at...
Marco Valgimigli, En...
dual antiplatelet therapy, PCI, drug-eluting stent, bleeding risk, sirolimus-eluting stent, MASTER DAPT trial, ischemic events, abbreviated therapy, major bleeding, cardiovascular outcomes

This multicenter randomized trial (MASTER DAPT) evaluated abbreviated vs. standard-duration dual ant... 6 days ago

Examining Examinations Conducted under Anesthesia
Michael F. Greene, M...
Informed consent, medical trainees, anesthesia, pelvic examinations, patient autonomy, medical ethics

This perspective article addresses the ethical and practical challenges surrounding medical trainees... 6 days ago

Drawing Boundaries around PARADISE
Lynne W. Stevenson, ...
PARADISE-MI, sacubitril–valsartan, acute myocardial infarction, heart failure, RAAS, neprilysin inhibition, clinical trial boundaries, hypotension, editorial commentary, post-MI therapy

This editorial examines the outcomes and clinical implications of the PARADISE-MI trial, which asses... 6 days ago

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