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Vutrisiran in Patients with Transthyretin Amyloido...
M. Fontana, J.L. Ber...
ATTR amyloidosis, vutrisiran, RNA interference therapy, transthyretin cardiomyopathy, tafamidis, HELIOS-B trial, cardiovascular outcomes, heart failure, mortality risk reduction, quality of life improvement

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease caused by mi... 4 weeks ago

Vaginal Varix in Pregnancy
Sara Tameish, M.D.; ...
vaginal varix, pregnancy complications, high-risk obstetrics, vascular lesion, transvaginal ultrasonography, color Doppler, hormonal changes, pelvic vein compression

A 31-year-old woman at 35 weeks and 2 days' gestation was referred to a high-risk obstetrics clinic ... 4 weeks ago

The Way to a Patient’s Heart — Vascular Access...
Niklas Nielsen, M.D....
cardiac arrest, vascular access, intraosseous access, intravenous access, resuscitation, emergency medicine, PARAMEDIC-3 trial, IVIO trial, survival outcomes, CPR guidelines

This editorial reviews two randomized clinical trials evaluating vascular access strategies for drug... 4 weeks ago

The Role of Importation in Remediating U.S. Generi...
Thomas J. Bollyky, J...
drug shortages, generic medicines, FDA regulation, sterile injectables, pharmaceutical importation, benzathine , patient safety, regulatory frameworks

The ongoing shortage of generic drugs in the United States, particularly sterile injectable medicine... 4 weeks ago

The Pediatrician's Lament
Eleanor R. Menzin, M...
pediatric vaccines, vaccine hesitancy, immunization advocacy, public health, infectious disease prevention, medical ethics, healthcare policy, childhood vaccinations

This perspective explores the ethical responsibility of pediatricians in promoting vaccinations amid... 4 weeks ago

Sport-Related Concussion
John J. Leddy, M.D.
sport-related concussion, mild traumatic brain injury, vestibular dysfunction, oculomotor impairment, cognitive rest, aerobic exercise, cervical injury

Sport-related concussion is classified as a mild traumatic brain injury (TBI) resulting from direct ... 4 weeks ago

See the Harm
The New England Jour...
medical education, clinical training, patient-centered care, pathology, empathy, heart failure, neurodegenerative disease, medical student reflections, learning through illness, human suffering

A third-year medical student reflects on the paradox of learning through patient suffering. The narr... 4 weeks ago

Schrödinger’s Cancer
Mark Earnest, M.D., ...
medical uncertainty, Schrödinger’s cat, existential psychology, diagnostic imaging, cancer screening, patient decision-making, healthcare delay, personal narrative, probability in medicine, psychological resilience

This personal narrative explores the psychological and existential dimensions of awaiting a critical... 4 weeks ago

Open and Endoscopic Carpal-Tunnel Release
Atilla Emin, M.B., C...
carpal tunnel syndrome, surgical release, open technique, endoscopic technique, median nerve compression, postoperative recovery, nerve damage, surgical anatomy, rehabilitation, complication management

Carpal tunnel syndrome affects approximately 87 men and 192 women per 100,000 people worldwide, prim... 4 weeks ago

Miles to Go and Nowhere to Sleep
Heather Kovich, M.D.
rural healthcare, medical access, tertiary care centers, kidney stone treatment, health disparities, urban healthcare resources, patient lodging programs, healthcare equity, HOSTS for HOSPITALS, systemic healthcare reform

Rural patients often face significant barriers in accessing specialized medical care, particularly i... 4 weeks ago

Livedo Racemosa
Wei-Yao Wang, M.D.; ...
livedo racemosa, livedo reticularis, metastatic breast cancer, tumor embolism, cytokeratin 7, cutaneous blood flow, dermatology, biopsy findings, thromboembolic disorders, chemotherapy

A 66-year-old woman with metastatic breast cancer presented with an asymptomatic, fragmented, netlik... 4 weeks ago

Intraosseous or Intravenous Vascular Access for Ou...
M.F. Vallentin, A. G...
out-of-hospital cardiac arrest, intraosseous access, intravenous access, vascular access, resuscitation, emergency medicine, randomized clinical trial, survival, neurologic outcomes, epinephrine administration

Out-of-hospital cardiac arrest is a leading global cause of mortality, necessitating rapid vascular ... 4 weeks ago

Infrequent Zoledronate — Small Individual Gain, ...
Roland Chapurlat, M....
fragility fractures, postmenopausal women, osteoporosis, osteopenia, zoledronate, bisphosphonates, fracture prevention, primary prevention, randomized controlled trial, bone mineral densit

Fragility fractures impose substantial burdens on postmenopausal women, with approximately 75% occur... 4 weeks ago

Heart Failure with Preserved Ejection Fraction
Antonio Cannata, M.D...
heart failure with preserved ejection fraction, ejection fraction, hypertension, diabetes, obesity, natriuretic peptides, echocardiography, diuretics, SGLT2 inhibitors, GLP-1 receptor agonists

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous condition affecting up to ... 1 month ago

Gender-Affirming Surgical Care in Carceral Setting...
Matthew Murphy, M.D...
gender-affirming care, transgender health, incarceration, surgical affirmation, WPATH standards, prison healthcare, mental health, healthcare equity, Medicaid waivers, housing policies

Transgender and gender-nonconforming persons are incarcerated at disproportionate rates in the Unite... 1 month ago

Fracture Prevention with Infrequent Zoledronate in...
Mark J. Bolland, M.B...
zoledronate, fracture prevention, early postmenopausal women, vertebral fracture, bone mineral density, osteoporosis, randomized controlled trial, placebo-controlled study, bone turnover markers, bisphosphonate therapy

Zoledronate has demonstrated efficacy in fracture prevention for older women with osteoporosis, but ... 1 month ago

FAIRS — A Framework for Evaluating the Inclusio...
Katherine E. Goodman...
clinical algorithms, sex-based variables, prognostic necessity, algorithm bias, medical decision-making, health equity, legal standards, FAIRS framework, patient care, algorithm ethics

The FAIRS framework (Framework for Algorithm Inclusion Review for Sex) is designed to evaluate the e... 1 month ago

Exogenous Lipoid Pneumonia
Taichi Kaneko, M.D....
exogenous lipoid pneumonia, lipid-laden macrophages, eating disorder, aspiration pneumonia, bronchoscopy, computed tomography, histopathology, cognitive behavioral therapy, pulmonary evaluation, radiologic resolution

A 38-year-old woman was referred for evaluation of an opacity in the right lower lung lobe. Despite ... 1 month ago

Deciding Whether to Accept an Unvaccinated Child ...
Ann Cheung, M.D.
vaccine hesitancy, pediatric practice, measles, mumps, rubella, alternative immunization schedule, public health, parental autonomy, medical ethics, infectious disease prevention, vaccine refusal

A pediatric practice faces the ethical and practical dilemma of whether to accept an 18-month-old ch... 1 month ago

Darier’s Sign in Solitary Mastocytoma
Haleigh Dawn Staffor...
solitary mastocytoma, Darier’s sign, pediatric dermatology, cutaneous mastocytosis, mast-cell disease, glucocorticoid ointment, histamine release, skin lesion, erythema, diphenhydramine

   A previously healthy 10-month-old girl presented with an intermittently itchy and swoll... 1 month ago

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