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Decline in Pathogenic Antibodies over Time in VITT
Linda Schönborn, Th...
VITT, vaccine-induced immune thrombotic thrombocytopenia, PF4 antibodies, ELISA, thrombocytopenia, platelet activation, mRNA vaccination, Covid-19, adenoviral vector vaccine, antibody persistence

This correspondence presents findings from a follow-up study of 35 patients in Germany with vaccine-... 6 days ago

Daprodustat for the Treatment of Anemia in Patient...
Ajay K. Singh, Kevin...
daprodustat, chronic kidney disease, anemia, nondialysis, HIF prolyl hydroxylase inhibitor, darbepoetin alfa, ASCEND-ND, hemoglobin, cardiovascular safety, erythropoiesis

This phase 3 randomized trial (ASCEND-ND) compared oral daprodustat, a hypoxia-inducible factor prol... 6 days ago

Copycat
Brett W. Dietz, Lisa...
Bartonella henselae, endocarditis, glomerulonephritis, cryoglobulinemia, hepatitis C, vasculitis, confirmation bias, diagnostic heuristics, culture-negative endocarditis, renal pathology

This Clinical Problem-Solving article presents a diagnostically complex case involving a 75-year-old... 6 days ago

Copycat
Brett W. Dietz, Lisa...
Bartonella henselae, endocarditis, glomerulonephritis, cryoglobulinemia, hepatitis C, vasculitis, confirmation bias, diagnostic heuristics, culture-negative endocarditis, renal pathology

This Clinical Problem-Solving article presents a diagnostically complex case involving a 75-year-old... 6 days ago

Clinical Features of Vaccine-Induced Immune Thromb...
Sue Pavord, Marie Sc...
VITT, ChAdOx1 nCoV-19, thrombocytopenia, cerebral venous sinus thrombosis, anti-PF4 antibodies, D-dimer, fibrinogen, IVIG, vaccine safety, plasma exchange

This prospective cohort study described 220 patients in the United Kingdom diagnosed with vaccine-in... 6 days ago

Elagolix for Heavy Menstrual Bleeding in Women wi...
Silverio Perrotta, D...
Elagolix, uterine fibroids, heavy menstrual bleeding, GnRH antagonist, add-back therapy, clinical trial

This study evaluated the efficacy and safety of elagolix, an oral gonadotropin releasing hormone (Gn... 6 days ago

Chlorthalidone in Advanced Chronic Kidney Disease ...
David C. Wheeler, M....
chlorthalidone, chronic kidney disease, hypertension, thiazide diuretics, intraglomerular pressure, albuminuria, ACE inhibitors, ARBs, blood pressure control, editorial commentary

This editorial reviews the CLICK trial, which tested chlorthalidone in patients with stage 4 chronic... 6 days ago

Chlorthalidone for Hypertension in Advanced Chroni...
Rajiv Agarwal, Arjun...
chlorthalidone, hypertension, chronic kidney disease, CKD stage 4, thiazide diuretic, ambulatory blood pressure, albuminuria, NT-proBNP, renal protection, CLICK trial

This double-blind, placebo-controlled trial (CLICK) evaluated chlorthalidone in 160 patients with st... 6 days ago

Cardiovascular Events with Finerenone in Kidney Di...
Bertram Pitt, Gerasi...
finerenone, mineralocorticoid receptor antagonist, type 2 diabetes, chronic kidney disease, cardiovascular events, heart failure, albuminuria, kidney outcomes, hyperkalemia, FIGARO-DKD trial

This phase 3 randomized controlled trial (FIGARO-DKD) evaluated finerenone—a selective nonsteroida... 6 days ago

Effects of Germline VHL Deficiency on Growth, Meta...
Silverio Perrotta, D...
VHL deficiency, mitochondrial dysfunction, erythrocytosis, hypoxia-inducible factor, growth impairment, metabolic reprogramming

This study describes a patient with severe germline VHL deficiency due to a novel synonymous mutatio... 6 days ago

Cardiovascular and Renal Outcomes with Efpeglenati...
Hertzel C. Gerstein,...
efpeglenatide, GLP-1 receptor agonist, cardiovascular outcomes, renal outcomes, AMPLITUDE-O trial, type 2 diabetes, SGLT2 inhibitors, macroalbuminuria, MACE, diabetic nephropathy

This phase 3 randomized controlled trial (AMPLITUDE-O) evaluated efpeglenatide, a weekly GLP-1 recep... 6 days ago

Detection of Structural Rearrangements in Embryos
Svetlana Madjunkova,...
Preimplantation genetic testing, structural rearrangements, balanced chromosomal rearrangements, MinION sequencing, nanopore technology, IVF, breakpoint detection, PGT-SR

This study evaluated the use of MinION long-read nanopore sequencing for preimplantation genetic tes... 6 days ago

Can Salt Substitution Save At-Risk Persons from St...
Julie R. Ingelfinger...
salt substitute, stroke prevention, cardiovascular disease, potassium chloride, sodium chloride, hypertension, public health, hyperkalemia, SSaSS trial, rural health

This editorial reviews the Salt Substitute and Stroke Study (SSaSS), a cluster-randomized trial invo... 6 days ago

Adjunct Immune Globulin for Vaccine-Induced Immune...
Alex Bourguignon, Do...
VITT, IVIG, thrombocytopenia, ChAdOx1 nCoV-19, platelet activation, PF4 antibodies, serotonin-release assay, arterial thrombosis, disseminated intravascular coagulation, non-heparin anticoagulation

This brief report outlines the clinical and laboratory responses to high-dose intravenous immune glo... 6 days ago

Breaking New Ground with Incretin Therapy in Diabe...
Katherine R. Tuttle,...
tirzepatide, GLP-1 receptor agonist, GIP, type 2 diabetes, semaglutide, incretin therapy, weight loss, cardiovascular risk, kidney disease, trial diversity

This editorial reviews recent advances in incretin-based therapy for type 2 diabetes, focusing on ti... 6 days ago

Couvelaire Uterus
Pradip Dashraath, M....
Couvelaire uterus, placental abruption, concealed hemorrhage, uterine atony, emergency cesarean section, preterm delivery, uterotonics

This case report describes a 29 year old primigravida presenting at 33 weeks’ gestation with conce... 6 days ago

Anticoagulation after Ablation for Atrial Fibrilla...
Siri R. Kadire, M.D...
atrial fibrillation, anticoagulation, catheter ablation, CHA₂DS₂-VASc, HAS-BLED, stroke prevention, bleeding risk, shared decision making, Apple Watch, clinical guidelines

This Clinical Decisions article presents a case vignette of a 74-year-old man with persistent atrial... 6 days ago

Angiotensin Receptor–Neprilysin Inhibition in Ac...
Marc A. Pfeffer, Bri...
sacubitril–valsartan, ramipril, PARADISE-MI, acute myocardial infarction, heart failure, angiotensin receptor–neprilysin inhibition, ACE inhibitor, cardiovascular death, hospitalization, randomized trial

This phase 3 randomized, double-blind trial PARADISE-MI compared sacubitril–valsartan to ramipril ... 6 days ago

Complications of Unsafe and Self-Managed Abortion
Lisa H. Harris, M.D....
Self-managed abortion, mifepristone, misoprostol, unsafe abortion, abortion complications, hemorrhage, sepsis, uterine injury, legal restrictions, harm reduction

This review article examines the clinical and legal implications of unsafe and self-managed abortion... 6 days ago

Abelacimab for Prevention of Venous Thromboembolis...
Peter Verhamme, B. A...
abelacimab, factor XI, venous thromboembolism, total knee arthroplasty, enoxaparin, anticoagulant therapy, monoclonal antibody, thromboprophylaxis, bleeding risk, clinical trial

This phase 2 trial evaluated the efficacy and safety of abelacimab—a monoclonal antibody that lock... 6 days ago

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