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Severe HDL Cholesterol Reduction with Bempedoic A...
Francesco Sbrana et ...
HDL cholesterol, bempedoic acid, fenofibrate, drug interaction, familial hypercholesterolemia, stomatocytes

A low plasma level of high-density lipoprotein (HDL) cholesterol is a strong, independent predict... 2 months ago

Routine Cerebral Embolic Protection during Transc...
Rajesh K. Kharbanda ...
TAVI, cerebral embolic protection, stroke, randomized trial, aortic stenosis, CEP device

Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral... 2 months ago

Pulsed Field or Cryoballoon Ablation for Paroxys...
Tobias Reichlin et a...
pulsed field ablation, cryoballoon ablation, paroxysmal atrial fibrillation, pulmonary-vein isolation, nonthermal ablation, implantable cardiac monitor, arrhythmia recurrence, catheter ablation, randomized trial, SINGLE SHOT CHAMPION trial

Background: Pulmonary-vein isolation is effective for paroxysmal atrial fibrillation (AF). Pulsed fi... 2 months ago

Oral Semaglutide and Cardiovascular Outcomes in H...
D.K. McGuire et al. ...
oral semaglutide, type 2 diabetes, cardiovascular outcomes, GLP-1 receptor agonist, MACE, atherosclerotic cardiovascular disease, chronic kidney disease, myocardial infarction, randomized controlled trial, SOUL trial

Background:The cardiovascular safety of oral semaglutide, a glucagon-like peptide-1 (GLP-1) recep... 2 months ago

Modest Blood Pressure Increase with Age in Adults...
Andrea Kelly et al.
Down’s syndrome, blood pressure, hypertension, systolic blood pressure, diastolic blood pressure, pulse pressure, cardiovascular phenotype, aging, BMI, sympathetic activity

Background: In the general population, blood pressure typically rises with age, but this pattern in ... 2 months ago

Medium- and Distal-Vessel Occlusion — The Limit ...
J. Mocco, M.D
thrombectomy, stroke, medium-vessel occlusion, distal-vessel occlusion, ESCAPE-MeVO trial, DISTAL trial, ischemic stroke, endovascular therapy, mortality, intracranial hemorrhage

Background: Thrombectomy for stroke has shown significant benefits in large-vessel occlusions, but i... 2 months ago

Lorundrostat Efficacy and Safety in Patients with...
L.J. Laffin et al. f...
lorundrostat, hypertension, aldosterone synthase inhibitor, randomized controlled trial, ambulatory blood pressure, hyperkalemia, treatment-resistant hypertension, eGFR, mineralocorticoid, cardiovascular risk

Background: Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone sy... 2 months ago

Lepodisiran — A Long-Duration Small Interfering ...
Steven E. Nissen, We...
Lepodisiran, lipoprotein(a), siRNA therapy, cardiovascular disease, RNA interference, ALPACA trial, LDL cholesterol, atherosclerosis, PCSK9 inhibitors, Eli Lilly.

"BACKGROUNDElevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular... 2 months ago

Left Atrial Appendage Closure after Ablation for ...
O.M. Wazni, W.I. Sal...
Atrial fibrillation, catheter ablation, pulsed field ablation, cryoballoon ablation, pulmonary-vein isolation, SINGLE SHOT CHAMPION trial, arrhythmia monitoring, patient-centric outcomes, cardiac electrophysiology.

"BACKGROUNDOral anticoagulation is recommended after ablation for atrial fibrillation among patie... 2 months ago

Intensive Blood-Pressure Control in Patients with...
Y. Bi, M. Li, Y. Liu...
Type 2 diabetes, intensive blood-pressure control, systolic blood pressure, cardiovascular events, hypertension, randomized controlled trial, BPROAD trial, China, hypotension, hyperkalemia.

"BACKGROUNDEffective targets for systolic blood-pressure control in patients with type 2 diabetes ar... 2 months ago

Heart Rhythm Interventions — Devil in the Detail...
Jason G. Andrade, M....
Atrial fibrillation, catheter ablation, pulsed field ablation, cryoballoon ablation, pulmonary-vein isolation, SINGLE SHOT CHAMPION trial, arrhythmia monitoring, patient-centric outcomes, cardiac electrophysiology

Atrial fibrillation is the most common cardiac arrhythmia encountered in clinical practice. Percu... 2 months ago

Global Effect of Cardiovascular Risk Factors on L...
Christina Magnussen ...
cardiovascular disease, lifetime risk, risk factors, hypertension, hyperlipidemia, obesity, diabetes, smoking, life expectancy, risk modification, global health, population-based cohort, prevention strategies

BACKGROUND Five risk factors account for approximately 50% of the global burden of cardiovascular d... 2 months ago

Extended Reduced-Dose Apixaban for Cancer-Associa...
I. Mahe, M. Carrier,...
Apixaban, cancer-associated thrombosis, venous thromboembolism, extended anticoagulation, reduced-dose, bleeding risk, randomized controlled trial, API-CAT study.

BACKGROUNDIn patients with active cancer and venous thromboembolism, whether extended treatment w... 2 months ago

Endovascular Treatment of Stroke Due to Medium-Ve...
M. Goyal, J.M. Ospel...
Endovascular thrombectomy (EVT), medium-vessel occlusion, acute ischemic stroke, randomized controlled trial, modified Rankin scale, intracranial hemorrhage, ESCAPE-MeVO trial.

BACKGROUNDWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-v... 2 months ago

Endovascular Treatment for Stroke Due to Occlusio...
M. Psychogios, A. Br...
Endovascular treatment, stroke, medium vessel occlusion, distal vessel occlusion, thrombectomy, modified Rankin scale, best medical treatment, randomized controlled trial

BACKGROUNDEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and... 2 months ago

Dapagliflozin in Patients Undergoing Transcatheter...
S. Raposeiras-Roubin...
Dapagliflozin, transcatheter aortic-valve implantation (TAVI), aortic stenosis, heart failure, SGLT2 inhibitors, cardiovascular outcomes, elderly patients, randomized controlled trial, adverse events, cardiology.

BACKGROUNDSodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of heart-failure admissi... 2 months ago

Clearing the Smoke on Fossil Fuels — The Health...
Linda Rudolph, Vishn...
Fossil fuels, public health, countermarketing, climate change, air pollution, health disparities, tobacco industry tactics, greenwashing, policy advocacy, environmental justice.

This perspective advocates for a public health countermarketing campaign against fossil fuels, mo... 2 months ago

Cancer-Associated Venous Thromboembolism — Beyo...
Simon Noble, Mahé ...
Cancer-associated thrombosis, venous thromboembolism, anticoagulation, apixaban, API-CAT trial, low-molecular-weight heparin, direct oral anticoagulants, bleeding risk, oncology, personalized medicine.

This editorial discusses the management of cancer-associated venous thromboembolism (VTE) beyond the... 2 months ago

Beta-Blocker Therapy after Acute Myocardial Infar...
Christos P. Kotanidi...
Beta-blocker therapy, acute myocardial infarction, preserved ejection fraction, NSTEMI, secondary prevention, REDUCE-AMI trial, clinical guidelines, cardiology, revascularization, evidence-based medicine.

This clinical debate examines whether beta-blocker therapy should be recommended for a 54-year-ol... 2 months ago

Modest Blood Pressure Increase with Age in Adults ...
Andrea Kelly, M.D., ...
Down's syndrome, hypertension, systolic blood pressure, diastolic blood pressure, pulse pressure, cardiovascular phenotype, arterial stiffness, sympathetic activity, age-related blood pressure trends, body-mass index (BMI)

In contrast to the general population, where systolic blood pressure (SBP) rises with age and diasto... 2 months ago

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