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A Randomized Trial of Automated Insulin Delivery i...
Y.C. Kudva, D. Raghi...
Automated insulin delivery, type 2 diabetes, randomized trial, glycated hemoglobin, continuous glucose monitoring, hyperglycemia, hypoglycemia

Automated insulin delivery (AID) systems have shown benefits for patients with type 1 diabetes, but ... 3 months ago

HIV-Positive Organ Donation as Standard of Care in...
Elmi Muller
HIV-positive organ donation, kidney transplantation, HOPE Act, HIV-positive donors, HIV-positive recipients, antiretroviral therapy, immunosuppression, graft survival, viral strain introduction, ethical transplantation

This editorial reflects on the historical, ethical, and clinical evolution of HIV-positive organ don... 3 months ago

HIV-Associated Tuberculosis
Graeme Meintjes, Gar...
HIV-associated tuberculosis, CD4+ T-cell depletion, granuloma dysfunction, extrapulmonary TB, disseminated TB, immune reconstitution inflammatory syndrome (IRIS), rifampin interactions, dolutegravir dosing, Xpert MTB/RIF

This comprehensive review examines the epidemiology, immunopathogenesis, diagnosis, treatment, and p... 3 months ago

Going Down the Rabbit Hole
Kendall J. Burdick, ...
tularemia, Francisella tularensis, prolonged pediatric fever, oropharyngeal tularemia, zoonotic infection, spring water ingestion, necrotizing lymphadenitis, cervical adenopathy, gentamicin treatment, ciprofloxacin

This case chronicles the diagnostic journey of an 8-year-old girl with prolonged fever, pharyngitis,... 3 months ago

Genital Herpes Zoster
Chengbei Bao, Chao J...
genital herpes zoster, S2 dermatome, varicella-zoster virus, postherpetic neuropathy, urinary retention, rheumatoid arthritis, immunosuppression, valaciclovir, pregabalin, intermittent catheterization

   A 70-year-old man with rheumatoid arthritis and immunosuppressive therapy presented wit... 3 months ago

Fundamentals of Medical Ethics — Medical Experti...
Barron H. Lerner
medical ethics, patient trust, cultural authority, informed consent, shared decision-making, medical misinformation, physician–patient communication, Covid-19 vaccine hesitancy, civil rights, feminist health activism

This Perspective examines the evolving crisis of medical expertise and trust in the U.S., especially... 3 months ago

Fractional Doses of Pneumococcal Conjugate Vaccine...
K.E. Gallagher, R. L...
PCV13, PCV10, pneumococcal conjugate vaccine, fractional dose, noninferiority trial, immunogenicity, IgG threshold, vaccine-serotype carriage, Kenya, Gavi transition, cost-effective immunization, pediatric vaccination schedule

This randomized trial conducted in Kenya tested whether fractional doses (20% and 40%) of 10-valent ... 3 months ago

Fight or Flight — Facing the Marburg Outbreak in...
Jean Pierre Sibomana
Marburg virus disease (MVD), Rwanda outbreak, viral hemorrhagic fever, critical care decision-making, empirical therapy failure, blood-streaked intubation, ICU containment, remdesivir, monoclonal antibody therapy, Marburg vaccine

This firsthand account documents the clinical and ethical decision-making of a critical care physici... 3 months ago

Features of HIV Infection in the Context of Long-A...
Raphael J. Landovitz...
CAB-LA, HIV PrEP, long-acting antiretrovirals, LEVI syndrome, delayed seroconversion, HIV RNA testing, diagnostic algorithm, INSTI resistance, integrase strand transfer inhibitors, cabotegravir, dolutegravir resistance

   This letter outlines unusual clinical and laboratory features of HIV infection during l... 3 months ago

Eyelid Ecchymoses and Subconjunctival Hemorrhage i...
Leopold Simma, Maxin...
pertussis, eyelid ecchymoses, subconjunctival hemorrhage, Bordetella pertussis, whooping cough, venous pressure, paroxysmal cough, pediatric emergency, clarithromycin, cough-related complications

A previously healthy 10-year-old boy presented with a 4-day history of progressive eyelid bruising f... 3 months ago

Extensive Tinea Corporis and Tinea Cruris from Tri...
Ziyang Xu, Avrom S. ...
tinea corporis, tinea cruris, Trichophyton indotineae, antifungal resistance, travel-associated infection, itraconazole, extensive dermatophyte infection, topical antifungal failure, genetic sequencing, emerging pathogen, South Asia

A previously healthy 30-year-old man developed an extensive, itchy rash over six months during migra... 3 months ago

Erysipelas
Nathan I. Wood, Andr...
erysipelas, Streptococcus pyogenes, peau d’orange, facial rash, Crohn’s disease, infliximab, immunosuppression, cephalexin, intravenous penicillin, blood culture, dermal infection, malar region, upper dermis

   A 44-year-old man with Crohn’s disease receiving infliximab therapy presented with a ... 3 months ago

Efforts Toward Equity
Peter T. Masiakos, C...
health equity, community-centered storytelling, trauma-informed care, mentorship model, STEM+M pathways, racial inclusion, demographic data collection, Covered California, food insecurity, urban farming, VeggieRx

This multi-article Perspective series showcases innovative responses to inequity in U.S. health care... 3 months ago

Vitamin D–Binding Protein Deficiency and Homozyg...
Clark M. Henderson, ...
Vitamin D–binding protein, GC gene deletion, ankylosing spondylitis, vitamin D deficiency, free-hormone hypothesis, osteopenia, consanguinity

This brief report describes a 58 year old woman with severe ankylosing spondylitis and consanguineou... 3 months ago

Vitamin D Supplementation and Prevention of Type 2...
Anastassios G. Pitta...
Vitamin D, type 2 diabetes prevention, prediabetes, randomized controlled trial, glycemic control, 25-hydroxyvitamin D

This multicenter, randomized, placebo controlled trial investigated whether vitamin D₃ supplementa... 3 months ago

VITAL Signs for Dietary Supplementation to Prevent...
John F. Keaney, Jr.,...
Dietary supplements, vitamin D, omega-3 fatty acids, cancer prevention, cardiovascular disease, VITAL trial, primary prevention

This editorial evaluates the findings of the VITAL trial, a large scale randomized study testin... 3 months ago

Traveling down the Long Road to Type 1 Diabetes Me...
Clifford J. Rosen, J...
Type 1 diabetes prevention, teplizumab, autoimmune disease, CD3 antibody, beta-cell destruction, clinical trial

This editorial explores the progress and challenges in preventing type 1 diabetes mellitus (T1DM), a... 3 months ago

Toward Automated Insulin Delivery
Daniela Bruttomesso
Automated insulin delivery, closed-loop system, type 1 diabetes, glycemic control, hybrid closed-loop, Tandem Control-IQ

This editorial discusses the advancements in automated insulin delivery systems for patients with ty... 3 months ago

Ticagrelor in Patients with Stable Coronary Diseas...
P.G. Steg, D.L. Bhat...
Ticagrelor, stable coronary artery disease, diabetes, aspirin, cardiovascular events, major bleeding

In patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial ... 3 months ago

Thyroid Function and Conception
Angela X. Chen, Ange...
Thyroid function, conception, miscarriage, levothyroxine, thyroid peroxidase antibodies, pregnancy, hypothyroidism

This clinical decision article examines whether to initiate levothyroxine treatment in a 31 year old... 3 months ago

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